26518-76-3

Usage

Uses

Used in Pharmaceutical Industry:
6-(Chloroacetyl)-2H-1,4-benzoxazin-3(4H)-one is used as a synthetic intermediate for the preparation of various pharmaceutical compounds. Its unique structure allows for the creation of a wide range of molecules with potential therapeutic applications.
Used in Chemical Synthesis:
6-(Chloroacetyl)-2H-1,4-benzoxazin-3(4H)-one is used as a key building block in the synthesis of complex organic molecules, particularly in the development of novel chemical entities with potential applications in various industries, such as pharmaceuticals, agrochemicals, and materials science.
Used in the Preparation of Specific Compounds:
6-(Chloroacetyl)-2H-1,4-benzoxazin-3(4H)-one is used as a starting material for the preparation of [2-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-carbonyl)-1H-indol-3-yl]acetic acids and N-alkyl 6-[2-(4,6-diphenylpyridyl)]-2H-[1,4]benzoxazin-3-one. These compounds may have potential applications in various fields, such as pharmaceuticals or materials science, due to their unique structures and properties.

InChI:InChI=1/C10H8ClNO3/c11-4-8(13)6-1-2-9-7(3-6)12-10(14)5-15-9/h1-3H,4-5H2,(H,12,14)

Upstream product

• 5466-88-6 3,4-dihydro-3-oxo-2H-1,4-benzoxazine 
• 79-04-9 chloroacetyl chloride 
• 137-07-5 2-amino-benzenethiol 

Downstream Products

• 6238-95-5 6-ethyl-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 114566-45-9 6-(2-phenyl-thiazol-4-yl)-4H-benzo[1,4]oxazin-3-one 
• 114566-47-1 6-[2-(4-chloro-phenyl)-thiazol-4-yl]-4H-benzo[1,4]oxazin-3-one 
• 114566-46-0 6-(2-Benzyl-thiazol-4-yl)-4H-benzo[1,4]oxazin-3-one 
• 114566-58-4 6-[2-(4-Chloro-phenylamino)-thiazol-4-yl]-4H-benzo[1,4]oxazin-3-one 
• 114566-48-2 6-[2-(4-Methoxy-phenyl)-thiazol-4-yl]-4H-benzo[1,4]oxazin-3-one 
• 114566-57-3 6-(2-p-Tolylamino-thiazol-4-yl)-4H-benzo[1,4]oxazin-3-one 
• 114566-59-5 6-[2-(4-Bromo-phenylamino)-thiazol-4-yl]-4H-benzo[1,4]oxazin-3-one 
• 507256-69-1 (4-chloro-phenyl)-acetic acid 2-oxo-2-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl ester 
• 454663-17-3 (4-methoxy-phenyl)-acetic acid 2-oxo-2-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl ester 
• 455297-48-0 (3,4-dimethoxy-phenyl)-acetic acid 2-oxo-2-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl ester 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF

The present invention provides a heterocyclic compound represented by the formula (I), its stereoisomers, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and their use in preparing a medicament for the prevention and/or treatment of central nervous system disease.

Synthesis of 6-(5-oxo-4-phenyl-2,5-dihydrofuran-3-yl)-2H-1,4-benzoxazin-3(4H)-one as potential non-steroidal anti-inflammatory agents (NSAIDS)

The synthesis and non-steroidal anti-inflammatory activity of a series 6-(5-oxo-4-phenyl-2,5-dihydrofuran-3-yl)-2H-1,4-benzoxazin-3(4H)-one are reported. The results showed that some of the furanones have shown marginal activity with reference to Rofecoxi

Studies on the synthesis of 6-(substituted pyridyl)-2H-[1,4] benzoxazin-3(4H)-one derivatives

6-Chloroacetyl-2H-[1,4]benzoxazin-3(4H)-one 1 is heated with pyridine to obtain 2H-[1,4]benzoxazin-3,4-dihydro-3-oxo-6-acetyl pyridinium chloride 2. 2 on reaction with a variety of chalcones 3 in the presence of ammonium acetate in acetic acid gives 6-(substituted pyridyl)-2H-[1,4]benzoxazin-3(4H)-one 4. Alkylation of 4a (R=R′=Ph) with various alkylating agents yields N-alkyl 6-[2-(4,6-diphenylpyridyl)]-2H-[1,4]benzoxazin-3-one 5, whose structures are supported by spectral and analytical data.

Synthesis and Biological Activity of Some New 6-Isothiocyanato-, 6-N-(N,N-Bis(methoxycarbonyl)guanidino)-, and 6-(2-Aryl/2-Arylaminothiazol-4-yl)-2H-1,4-benzoxazin-3(4H)-ones

Several new 6-isothiocyanato-2-arylidene/heteroarylidene-2H-1,4-benzoxazin-3(4H)-ones (3a-g), 2-arylidene/heteroarylidene-6-N--2H-1,4-benzoxazin-3(4H)-ones (4a-g) and 6-(2-aryl/2-arylaminothiazol-4-yl)2H-1,4-benzoxazin-3