2653-14-7

Upstream product

• 758640-21-0 N-Benzylaniline 
• 79-04-9 chloroacetyl chloride 
• 4015-58-1 monochloroacetic acid anhydride 
• 538-51-2 benzylidene phenylamine 
• 100-52-7 benzaldehyde 
• 62-53-3 aniline 

Downstream Products

• 861062-41-1 phenylsulfanyl-acetic acid-(N-benzyl-anilide) 
• 857947-93-4 (2-dimethylamino-ethoxy)-acetic acid-(N-benzyl-anilide) 
• 79143-76-3 [(Benzyl-phenyl-carbamoyl)-methyl]-diethyl-[(2,4,6-trimethyl-phenylcarbamoyl)-methyl]-ammonium; chloride 
• 94445-30-4 5-methyl-1,2,4-thiadiazolo<2,3-c>-quinazolin-2-thione 
• 76989-42-9 2-<(5-methyl-s-triazolo<4,3-c>quinazolin-3-yl)-thiol>-N,N-benzylphenylacetamide 
• 94445-31-5 [1-Ethoxy-2-methyl-1H-quinazolin-(4Z)-ylidene]-dithiocarbamic acid (benzyl-phenyl-carbamoyl)-methyl ester 
• 928156-24-5 3,3,7,7-tetra[N-benzyl-N-phenyl(acetamide)-2-oxymethyl]-5-oxanonane 
• 1217-89-6 1-benzylisatin 
• 7135-32-2 1-benzylindolin-2-one 

Relevant academic research and scientific papers

Palladium-catalyzed olefination of aryl/alkyl halides with trimethylsilyldiazomethane via carbene migratory insertion

The direct olefination of aryl/alkyl halides with trimethylsilyldiazomethane (TMSD) as a C1- or C2-unit was achieved successfully via a metal carbene migratory insertion process, which offered a new access to afford (E)-vinyl silanes and (E)-silyl-substituted α,β-unsaturated amides in good yields and high chemoselectivity.

Discovery of novel N -phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis

In this paper, we describe the screening of a 14640-compound library using a novel whole mycobacteria phenotypic assay to discover inhibitors of EthR, a transcriptional repressor implicated in the innate resistance of Mycobacterium tuberculosis to the second-line antituberculosis drug ethionamide. From this screening a new chemical family of EthR inhibitors bearing an N-phenylphenoxyacetamide motif was identified. The X-ray structure of the most potent compound crystallized with EthR inspired the synthesis of a 960-member focused library. These compounds were tested in vitro using a rapid thermal shift assay on EthR to accelerate the optimization. The best compounds were synthesized on a larger scale and confirmed as potent ethionamide boosters on M. tuberculosis-infected macrophages. Finally, the cocrystallization of the best optimized analogue with EthR revealed an unexpected reorientation of the ligand in the binding pocket.

AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS

Compounds of the formula (I), and pharmaceutically acceptable salts thereof, are found to be antagonists of SNS sodium channels. They are therefore useful as analgesic and neuroprotective agents wherein: X is -N- or -CH-; n is from 0 to 3.

Synthesis of substituted oxindoles from α-chloroacetanilides via palladium-catalyzed C - H functionalization

A novel method for the synthesis of oxindoles is described. In the presence of catalytic palladium acetate and 2-(di-tert-butylphosphino)biphenyl, α-chloroacetanilides are converted to oxindoles in good to excellent yields with high functional group compatibility using triethylamine as a stoichiometric base. The cyclization is highly regioselective, obviating the need for prefunctionalized arenes. Plausible mechanistic pathways for the reaction are discussed. Copyright

One-Step Hydroamidation of a Schiff Base with Trichlorosilane

We have found that the treatment of a Schiff base (2) with trichlorosilane and chloroacetyl chloride results in a highly active chloroacetamide herbicide (1) in an excellent yield .This one-step hydroamidation reaction of a Schiff base is a useful synthet