26586-02-7Relevant academic research and scientific papers
Preparation method of 2-methyl-4-acetoxy-2-butenal with thermal stability
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Paragraph 0058-0077, (2021/11/06)
The invention discloses a preparation method of 2-methyl-4-acetoxy-2-butenal with thermal stability, which comprises the following steps: (1) carrying out gas-solid-liquid three-phase hydroisomerization reaction on 2-methylene-4-acetoxybutyraldehyde and a solvent under the action of a catalyst to generate 2-methyl-4-acetoxy-2-butenal; (2) after the reaction reaches a specified conversion rate, terminating the reaction, conducting cooling and filtering out the catalyst; and (3) rectifying and separating the solvent, hydrogenation by-products and unreacted raw materials in the system to obtain the product 2-methyl-4-acetoxy-2-butenal. In the step (1), active hydrogen in the used solvent is controlled to be less than or equal to 100mgKOH/kg in terms of hydroxyl value content. The 2-methyl-4-acetoxy-2-butenal provided by the invention is good in thermal stability, low in loss rate in a rectification separation process and low in cis-isomer content, and can better meet downstream requirements.
Synthetic method of trans-4-acetoxyl-2-methyl-2-butene-1-aldehyde
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Paragraph 0026; 0039; 0040, (2016/12/22)
The invention discloses a synthetic method of trans-4-acetoxyl-2-methyl-2-butene-1-aldehyde. The method comprises the steps that 3,4-diacetoxy-1-butene and synthetic gas are used as raw materials, a formylation reaction is carried out at the temperature o
Synthesis of fluorescently tagged isoprenoid bisphosphonates that inhibit protein geranylgeranylation
Maalouf, Mona A.,Wiemer, Andrew J.,Kuder, Craig H.,Hohl, Raymond J.,Wiemer, David F.
, p. 1959 - 1966 (2007/10/03)
Geminal bisphosphonates can be used for a variety of purposes in human disease including reduction of bone resorption in osteoporosis, treatment of fractures associated with malignancies of the prostate, breast, and lung, and direct anticancer activity ag
Structure assignment of lagunapyrone B by fluorous mixture synthesis of four candidate stereoisomers
Yang, Fanglong,Newsome, Jeffery J.,Curran, Dennis P.
, p. 14200 - 14205 (2008/02/10)
Techniques of fluorous mixture synthesis have been used to make four candidate stereoisomers for the natural product lagunapyrone B. A quasiracemic mixture of vinyl iodides whose component configurations at C19-21 were encoded by fluorous silyl groups was
Synthesis of (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate, a key intermediate in the biosynthesis of isoprenoids
Ward, Jane L.,Beale, Michael H.
, p. 710 - 712 (2007/10/03)
The synthesis of (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate (HMBPP) was described by regioselective hydroxylation and diphosphorylation of dimethylallyl alcohol. The synthesis started from commercially available 3-methylbut-2-en-1-ol. The 1-alcohol function of starting material was converted to the acetate by treatment with pyridine acetic anhydride. Selective allylic hydroxylation was achieved using selenium dioxide and tert-butyl hydro-peroxide.
New retinoid analogs from δ-pyronene, a natural synthon
Lambertin, Frederic,Wende, Martin,Quirin, Marie Jeanne,Taran, Martine,Delmond, Bernard
, p. 1489 - 1494 (2007/10/03)
δ-Pyronene (1), a readily available terpenic synthon, is an excellent raw material for the preparation of numerous terpenic intermediates. Original retinoid analogs such as 'iso'-retinyl acetate (5), 'iso'-retinal (6) and ethyl 'iso' retinoate (7), in which the cyclogeranyl moiety is functionalized in an unusual position, were prepared from δ-pyronene.
Process for producing branched aldehydes
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, (2008/06/13)
It is provided a process for industrially advantageously producing a branched aldehyde represented by the formula; STR1 ?wherein Y represents an acyl group of two or more carbon atoms; and X represents an acyloxymethyl group represented by --CH2/sub
Process for producing 4-substituted-2-butenals
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, (2008/06/13)
Described is a process for producing a 4-substituted-2-butenal represented by the following formula (1); STR1 (wherein X represents an acyloxy group or halogen atom; R represents hydrogen atom, an aliphatic hydrocarbon group or an aromatic hydrocarbon gro
Process for the manufacture of a gamma-halotiglic aldehyde
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, (2008/06/13)
A novel process for the manufacture of a γ-halotiglic aldehyde HalH2 C--CH=C(CH3)--CHO ?I!, wherein Hal signifies chlorine or bromine, comprises haloalkoxylating a 1-alkoxy-2-methyl-1,3-butadiene H2 C=CH--C(CH3)
Process for producing aldehyde derivatives
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, (2008/06/13)
The present invention provides a novel process for producing 4-acyloxy-2-methyl-2-buten-1-al readily in high yield from a readily available inexpensive industrial starting compound without using special reaction apparatuses and conditions.
