265980-86-7

Upstream product

• 14113-02-1 ethyl 8-chloro-8-oxooctanoate 
• 106-40-1 4-bromo-aniline 
• 14113-01-0 Ethyl hydrogen suberate 

Downstream Products

• 265980-87-8 monoethyl suberate [4-3H]anilide 
• 149648-14-6 N'-(4-bromophenyl)-N-hydroxyoctanediamide 

Relevant academic research and scientific papers

An efficient synthesis of N-hydroxy-N'-[4-3H]phenyloctanediamide ([4-3H]SAHA), a potent cytodifferentiating agent

We have developed an efficient synthesis of N-hydroxy-N'-[4-3H]phenyloctanediamide ([4-3H]SAHA) from the monoester of suberanilic acid. The starting material, a monoester of suberoyl chloride, was condensed with 4-bromoaniline in the presence of a base to give the 4-bromoanilide of monoethyl suberate in 92% yield. On further treatment with methanolic hydroxylamine hydrochloride and sodium methoxide, this compound gave 4-bromosuberanilohydroxamic acid in 94% yield. Catalytic tritium exchange of bromine using Pd/C in a tritium gas atmosphere resulted in [4-3H]SAHA with a specific activity of 2.49 Ci/mmol. From the key intermediate, 4-bromoanilide of monoethyl suberate by a non-catalytic tritium exchange reaction, we have also prepared [4-3H]SAHA with high specific activity of 27.5 Ci/mmol.

Synthesis and biological effects of small molecule enhancers for improved recombinant protein production in plant cell cultures

Histone deacetylases are involved in chromatin remodelling and thus play a vital role in the epigenetic regulation of gene expression. HDAC inhibitors alter the acetylation status of histone and non-histone proteins to regulate various cellular events suc