265981-13-3Relevant articles and documents
Synthesis process of 2-bromo-4-iodo-3-methylpyridine
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Paragraph 0030-0031; 0032-0033, (2021/01/24)
The invention provides a synthesis process of 2-bromo-4-iodo-3-methylpyridine. The process is characterized by comprising the following steps: S1, carrying out halogenation reaction on 2-bromopyridineserving as a raw material to generate 2-bromo-3-iodopyridine; and S2, carrying out a halogen dance reaction on the raw material 2-bromo-3-iodopyridine to generate 2-bromo-4-iodo-3-methylpyridine. According to the invention, cheap and easily available 2-bromopyridine is used as a raw material to synthesize the raw material 2-bromo-3-iodopyridine for the halogen dance reaction, the synthesis process is also researched and optimized, a step-by-step synthesis method is adopted and the connection sequence of functional groups is changed to break through the route, the overall yield after optimization is low, and then a one-pot synthesis method is researched according to a halogen dance reaction mechanism. The process route has the characteristics of high yield, good product quality, cheap andeasily available initial raw materials and the like.
Deprotonative metalation of chloro- and bromopyridines using amido-based bimetallic species and regioselectivity-computed CH acidity relationships
Snegaroff, Katia,Nguyen, Tan Tai,Marquise, Nada,Halauko, Yury S.,Harford, Philip J.,Roisnel, Thierry,Matulis, Vadim E.,Ivashkevich, Oleg A.,Chevallier, Floris,Wheatley, Andrew E. H.,Gros, Philippe C.,Mongin, Florence
experimental part, p. 13284 - 13297 (2012/02/03)
A series of chloro- and bromopyridines have been deprotometalated by using a range of 2,2,6,6-tetramethylpiperidino-based mixed lithium-metal combinations. Whereas lithium-zinc and lithium-cadmium bases afforded different mono- and diiodides after subsequent interception with iodine, complete regioselectivities were observed with the corresponding lithium-copper combination, as demonstrated by subsequent trapping with benzoyl chlorides. The obtained selectivities have been discussed in light of the CH acidities of the substrates, determined both in the gas phase and as a solution in THF by using the DFT B3LYP method.
Tris(2,2′-bipyridyl)ruthenium(II) with branched polyphenylene shells: A family of charged shape-persistent nanoparticles
Haberecht, Monika C.,Schnorr, Jan M.,Andreitchenko, Ekaterina V.,Clark Jr., Christopher G.,Wagner, Manfred,Muellen, Klaus
scheme or table, p. 1662 - 1667 (2009/02/06)
(Figure Presented) Cores for thought: Dendrimers based on an octahedral symmetry and with a central positively charged transition-metal complex have been prepared up to the third generation (see schematic representation). The shape-persistent dendrimers with a high density of aromatic rings are accessible by either a partly convergent synthesis or a divergent strategy in which the metal complex proved to be stable to high-temperature Diels-Alder reactions.