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Upstream product

• 100523-96-4 2-bromo-4-iodo-pyridine 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 265981-13-3 2-bromo-3-iodo pyridine 
• 51791-30-1 (2E)-3-(4-chlorophenyl)but-2-enenitrile 
• 58530-53-3 2,4-dibromopyridine 
• 1679-18-1 4-Chlorophenylboronic acid 
• 109-04-6 2-bromo-pyridine 
• 106-47-8 4-chloro-aniline 

Relevant academic research and scientific papers

A Dichotomy in Cross-Coupling Site Selectivity in a Dihalogenated Heteroarene: Influence of Mononuclear Pd, Pd Clusters, and Pd Nanoparticles-The Case for Exploiting Pd Catalyst Speciation

Site-selective dihalogenated heteroarene cross-coupling with organometallic reagents usually occurs at the halogen proximal to the heteroatom, enabled by intrinsic relative electrophilicity, particularly in strongly polarized systems. An archetypical exam

Preparation method of 4-aryl-2-halopyridine derivatives

4 -aryl -2 - halopyridine derivatives are disclosed. A process for preparing γ - enamine of α-unsaturated nitrile (single-activated) using a halogen source is provided to obtain high yield and efficiency under mild conditions by using 4 - a conventional double activated (double-activated -2 -) substrate through intramolecular cyclization using a halogen source.

Synthesis of 2-Arylpyridines and 2-Arylbipyridines via Photoredox-Induced Meerwein Arylation with in Situ Diazotization of Anilines

We report herein a sustainable method for the preparation of 2-arylpyridines through C-H arylation of pyridines using in situ formed diazonium salts (from commercially available aromatic amines) in the presence of a photoredox catalyst under blue light-emitting diode (LED) irradiation. The reaction is tolerant to a wide range of functional groups (e.g., halogen, nitrile, formyl, acetyl, ester). Applications to the C-H bond arylation of bipyridine ligands is also presented.

γ-Functionalization of α,β-Unsaturated Nitrile in Mild Condition: Versatile Synthesis of 4-Aryl-2-Bromopyridines

This report describes the synthesis of 4-aryl-2-halopyridines via γ-functionalization of α,β-unsaturated nitriles, which were obtained by the HWE reaction with the corresponding ketones. The key features of our methods involve a conjugated γ-enamine formation of α,β-unsaturated nitrile (enamino nitrile), followed by consecutive intramolecular cyclization, resulting in heteroaromatic compounds like 2-halopyridines, α-pyrone, etc.

A facile synthesis of 4-Ar-2-bromopyridine and its 2,2′-bipyridine derivatives

By means of selective cross-coupling of ArMgBr with 2-bromo-4-iodopyridine in the presence of a catalytic amount of Pd(PPh3)4, 4-Ar-2-bromopyridines were facilely one-step synthesized. These pyridine compounds were smoothly transform

A concise synthesis of 2,4-disubstituted pyridines: A convenient synthesis of 2-bromo-4-iodopyridine via halogen dance and its successive one-pot disubstitutions

As a key building block for 2,4-disubstituted pyridines, 2-bromo-4-iodopyridine was synthesized conveniently from 2-bromopyridine using LDA and I2 via 'halogen dance'. 2-Bromo-4-iodopyridine was then converted to other 2,4-diaryl pyridines and