26599-08-6Relevant academic research and scientific papers
Organocatalyzed [2+2] Cycloaddition Reactions between Quinone Imine Ketals and Allenoates
Liu, Teng,He, Chixian,Wang, Fan,Shen, Xiang,Li, Yongqin,Lang, Man,Li, Guijun,Huang, Chao,Cheng, Feixiang
, p. 518 - 526 (2020/10/12)
A new cycloaddition reaction of quinone imine ketals (QIKs), which could be utilized to the construction of functionalized azaspirocyclics under mild conditions, is described. This transformation involved a [2+2] cycloaddition reaction between QIKs and allenoates catalyzed by DABCO, and then treatment with 1 N HCl in one-pot. The strategy could provide a practical route to access azetidine-fused spirohexadienones in good to excellent yields and with high E -selectivity.
Substituted 3-benzylcoumarins as allosteric MEK1 inhibitors: Design, synthesis and biological evaluation as antiviral agents
Wang, Chao,Zhang, Hao,Xu, Fengrong,Niu, Yan,Wu, Yun,Wang, Xin,Peng, Yihong,Sun, Jing,Liang, Lei,Xu, Ping
, p. 6057 - 6091 (2013/06/27)
In order to find novel antiviral agents, a series of allosteric MEK1 inhibitors were designed and synthesized. Based on docking results, multiple optimizations were made on the coumarin scaffold. Some of the derivatives showed excellent MEK1 binding affinity in the appropriate enzymatic assays and displayed obvious inhibitory effects on the ERK pathway in a cellular assay. These compounds also significantly inhibited virus (EV71) replication in HEK293 and RD cells. Several compounds showed potential as agents for the treatment of viral infective diseases, with the most potent compound 18 showing an IC 50 value of 54.57 nM in the MEK1 binding assay.
Gold-catalyzed simultaneous formation of C-C, C=O, and C-F bonds in the presence of selectfluor: A synthesis of fluoroindenes from allene esters
Liu, Yunkui,Zhu, Jie,Qian, Jianqiang,Xu, Zhenyuan
supporting information; experimental part, p. 5411 - 5417 (2012/08/07)
An approach for the synthesis of fluorinated indene derivatives has been developed via a gold-catalyzed three-component tandem reaction between allene esters, Selectfluor, and water.
Expedient synthesis of α-substituted α,β-unsaturated γ-amino acids (dipeptide mimetics); Wittig reaction of α-amino aldehydes with α- substituted alkoxycarbonyl phosphoranes
Scholz, Dieter,Weber-Roth, Sabine,Macoratti, Elena,Francotte, Eric
, p. 1143 - 1155 (2007/10/03)
Reacting ethoxycarbonyl triphenyl phosphorane with activated alkylhalides in chloroform gave the ylides 4 - 12. They react smoothly and in general without racemisation with α-amino aldehydes resulting in the dipeptide mimetics 15 - 25. Exceptions are the
An intramolecular cobalt cyclisation for the construction of substituted pyrrolidines
Baldwin, Jack E.,Moloney, Mark G.,Parsons, Andrew F.
, p. 9373 - 9384 (2007/10/02)
Cobalt mediated cyclisations of a radical onto a substituted allylamine can be used to generate highly functionalised pyrrolidines. The facility of the ring closure depends on the nature of substituents on the alkene moeity. Dehydrocobaltation of the init
A CONVINIENT SYNTHESIS OF 3-BENZYL-4-SUBSTITUTED COUMARINS AND THEIR BENZO DERIVATIVES
Britto, Nirmala,Gore, Vinayak G.,Mali, R. S.,Ranade, A. C.
, p. 1899 - 1910 (2007/10/02)
It is reported in the literature that alkylation of simple (unsubstituted) phosphorane with alkyl halide in ethyl acetate leads to equimolar mixture of alkylated phosphorane and salt of the unsubstituted phosphorane.Here we report exclusive formation of a
