26650-74-8

Upstream product

• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 109-86-4 2-methoxy-ethanol 

Downstream Products

• 18343-31-2 2-chloro-4,6-bis-(2-methoxy-ethoxy)-[1,3,5]triazine 

Relevant academic research and scientific papers

TRIAZINE-2,4-DIONE DERIVATIVE AND MANUFACTURING METHOD THEREFOR

PROBLEM TO BE SOLVED: To provide a novel triazine-2,4-dione derivative having 2 glycidyl groups as a substituent binding to a nitrogen atom, and further a substituent containing an alkoxy group, and a manufacturing method therefor. SOLUTION: There is provided a triazine-2,4-dione derivative, which is represented by the following formula (1), and is liquid as a state of the material at 25°C, 101.3 kPa. In the formula, R1 represents an alkyl group having 1 to 10 carbon atoms, R2 and R3 represent each independently an alkylene group having 1 to 5 carbon atoms, m and n represent each independently an integer of 0 to 5, and total number of carbon atoms of -(R3O)n(R2O)mR1 group is 1 to 18. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

Design, Synthesis and Biological Evaluation of Novel Nonsteroidal Progesterone Receptor Antagonists Based on Phenylamino-1,3,5-triazine Scaffold

We report here the development of phenylamino-1,3,5-triazine derivatives as novel nonsteroidal progesterone receptor (PR) antagonists. PR plays key roles in various physiological systems, including the female reproductive system, and PR antagonists are promising candidates for clinical treatment of multiple diseases. By using the phenylamino-1,3,5-triazine scaffold as a template structure, we designed and synthesized a series of 4-cyanophenylamino-1,3,5-triazine derivatives. The synthesized compounds exhibited PR antagonistic activity, and among them, compound 12n was the most potent (IC50=0.30μM); it also showed significant binding affinity to the PR ligand-binding domain. Docking simulation supported the design rationale of the compounds. Our results suggest that the phenylamino-1,3,5-triazine scaffold is a versatile template for development of nonsteroidal PR antagonists and that the developed compounds are promising lead compounds for further structural development of nonsteroidal PR antagonists.

KINETICS OF FORMATION OF MONOALKOXY-s-TRIAZINES FROM CYANURIC CHLORIDE.

2-R-alkoxy-4,6-dichloro-s-triazines (I) are used as intermediates for synthesis of herbicides, and are obtained by reactions of 2,4, 6-trichloro-s-triazine (II) (cyanuric chloride) with various alcohols in aqueous-organic mixtures in presence of hydrogen chloride acceptors. The purpose of this work was to study the quantitive relationships of the main reaction of cyanuric chloride alkoxylation and of the competing reactions of hydrolysis and alkoxylation of compound (I), for optimization of production of monoalkoxy-s-triazines. It is found that the reaction temperature has a significant influence on the yield of 2-(2-R-ethoxy)-4, 6-dichloro-s-triazine; decrease of temperature raises the yield of (I) owing to decrease of the contributions of hydrolysis of compounds (I) and (II) and alkoxylation of (I). The asolute values of the rate constants of hydrolysis (k//3, k//4) and alkoxylation (k//2) decrease more rapidly than k//1 with decrease of temperature. This makes it possible to raise the selectivity of the process by raising the alkali concentration and lowering the reaction temperature.

HALOGENATED ETHERS. XXI. EFFECT OF TEMPERATURE AND SUBSTITUENT ON THE KINETIC OF THE FORMATION OF 2-(2-R-ETHOXY)-4,6-DICHLORO-SYM-TRIAZINES

The effect of temperature on the kinetics of the formation of 2-(2-R-ethoxy)-4,6-dichloro-sym-triazines from 2,4,6-trichloro-sym-triazine and 2-R-ethanol in the presence of alkali was investigated.The low values of the activation energy and the large negative values of the entropy indicate the participation of a stable intermediate in the investigated complex many-stage reaction.The mechanism of the process and the characteristics of the manifestation of isokinetic relationships are discussed.