26652-12-0Relevant articles and documents
Phenyl glycosides from the leaves of Flacourtia indica (Burm. f.) Merr (Salicaceae)
Lavaud, Catherine,Massiot, Georges,Nguyen, Phuc-Dam,Sayagh, Charlotte
, (2021)
Thirteen phenolic glycosides, together with fourteen various known compounds, were isolated from the methanolic extract of leaves of Flacourtia indica. Twelve of these were composed of gentisyl or salicyl alcohols, glycosylated on the phenol and acylated on the primary alcohol with various more or less oxidized forms of pyrocatechuic acid. A number of positions on the glucose or on the acid were further acylated by benzoic or cinnamic acid. In addition to these, a glucoside of a phenyl propanoid was also isolated. The gross structures were elucidated by spectroscopic means including 1D and 2D NMR experiments and HR-ESI-MS analyses. Several of these structures, for example, xylosmin, were previously described but it proved extremely difficult to conclude on their exact identity with the absence of clear data on absolute configuration in the literature.
Poliothrysoside and its derivatives as novel insulin sensitizers potentially driving AMPK activation and inhibiting adipogenesis
Sashidhara, Koneni V.,Singh, Suriya P.,Varshney, Salil,Beg, Muheeb,Gaikwad, Anil N.
, p. 570 - 577 (2014)
In our efforts to develop safe and active chemical entities from nature, we first identified poliothrysoside (1), a phytoconstituent isolated from Flacourtia indica, possessing antidiabetic potential. Subsequently, fifteen derivatives (2-16) were synthesi
