267223-87-0

Usage

Uses

Used in Pharmaceutical Industry:
BOC-D-MELEU-OH is used as a reagent for the preparation of dipeptide [(6-aminopyridin-3-yl)methyl]amide derivatives. These derivatives serve as inhibitors of kallikrein 1, an enzyme involved in various physiological processes and diseases. By inhibiting kallikrein 1, these derivatives can potentially be used in the treatment of conditions such as inflammation, pain, and cancer.

Upstream product

• 319-78-8 D-Isoleucine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 55721-65-8 Boc-D-Ile-OH 
• 74-88-4 methyl iodide 

Downstream Products

• 1194096-56-4 {(R)-1-[(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-dichloro-phenyl)-ethylcarbamoyl]-2-methyl-butyl}-methyl-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Trichormamides A and B with antiproliferative activity from the cultured freshwater cyanobacterium Trichormus sp. UIC 10339

Two new cyclic lipopeptides, trichormamides A (1) and B (2), were isolated from the cultured freshwater cyanobacterium Trichormus sp. UIC 10339. The strain was obtained from a sample collected in Raven Lake in Northern Wisconsin. The planar structures of trichormamides A (1) and B (2) were determined using a combination of spectroscopic analyses including HRESIMS and 1D and 2D NMR experiments. The absolute configurations of the amino acid residues were assigned by the advanced Marfey's method after acid hydrolysis. Trichormamide A (1) is a cyclic undecapeptide containing two d-amino acid residues (d-Tyr and d-Leu) and one β-amino acid residue (β-aminodecanoic acid). Trichormamide B (2) is a cyclic dodecapeptide characterized by the presence of four nonstandard α-amino acid residues (homoserine, N-methylisoleucine, and two 3-hydroxyleucines) and one β-amino acid residue (β-aminodecanoic acid). Trichormamide B (2) was cytotoxic against MDA-MB-435 and HT-29 cancer cell lines with IC50 values of 0.8 and 1.5 μM, respectively.