26734-07-6Relevant articles and documents
FLP behaviour of cationic titanium complexes with tridentate Cp, O, N -ligands: Highly efficient syntheses and activation reactions of C-X bonds (X = Cl, F)
Fischer, Malte,Schwitalla, Kevin,Baues, Svenja,Schmidtmann, Marc,Beckhaus, Ruediger
, p. 1516 - 1523 (2019)
The synthesis of cationic titanium complexes 4a,b with tridentate Cp,O,N-ligand frameworks, starting from the monopentafulvene complex Cp?Ti(Cl)(π-η5:σ-η1-C5H4CR2 (CR2 = adamantylidene) (1) and bidentate O,N-ligand precursors CH3C(O)CH2CH2NR2 (R = Et, CH2Ph) (L1a,b), in a high-yielding and efficient two-step synthetic pathway is described. The β-aminoketones L1a,b were synthesized by a herein reported solvent- and catalyst-free reaction. The reaction pathway involves insertion reactions, subsequent methylations and final activations with B(C6F5)3. NMR investigations of the cationic titanium complex 4a in deuterated dichloromethane revealed an ongoing selective reaction under formation of the cationic complex 5a-d2, which is the result of C-Cl bond cleavage. In addition to selective C-Cl bond activation reactions, C(sp3)-F bonds were activated by 4a,b, pointing out the special tm-FLP nature of 4a,b.
Nanocrystalline copper(II) oxide catalyzed aza-Michael reaction and insertion of α-diazo compounds into N-H bonds of amines
Kantam, M. Lakshmi,Laha, Soumi,Yadav, Jagjit,Jha, Shailendra
experimental part, p. 4467 - 4469 (2009/12/01)
Nanocrystalline copper(II) oxide efficiently catalyzed the conjugate addition of aliphatic amines to α,β-unsaturated compounds to produce β-amino compounds with excellent yields under mild reaction conditions. Similarly, Glycine esters are obtained in good yields by the insertion of α-diazoacetate into N-H bonds of amines. The catalyst is used for three cycles with minimal loss of activity.
1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU)-promoted efficient and versatile aza-Michael addition
Yeom, Chang-Eun,Kim, Mi Jeong,Kim, B. Moon
, p. 904 - 909 (2007/10/03)
A convenient and versatile method was developed for aza-Michael addition using a substoichiometric amount of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). Various nitrogen nucleophiles were efficiently introduced to α,β-unsaturated carbonyl compounds employing 0.5 equiv of DBU. Furthermore, other heteroatomic nucleophiles could also be introduced successfully under the same reaction conditions.