26734-08-7

Usage

Uses

Used in Pharmaceutical Synthesis:
4-Amino-2-methyl butane-2-ol is used as a reagent in the synthesis of pharmaceutical compounds, specifically for the production of tyrosine kinase 3 (FLT3) inhibitors based on 5-aryl-2-aminopyridines. FLT3 inhibitors are important in the treatment of certain types of cancers, such as acute myeloid leukemia (AML), by targeting the FLT3 receptor and inhibiting its signaling pathways, which play a crucial role in the growth and survival of cancer cells.
Used in Organic Synthesis:
Due to its reactive functional groups, 4-Amino-2-methyl butane-2-ol can be used as a building block or intermediate in the synthesis of various organic compounds. Its amino and hydroxyl groups can participate in a wide range of chemical reactions, such as nucleophilic substitution, acylation, and condensation reactions, making it a valuable component in the development of new molecules with potential applications in various industries.
Used in Chemical Research:
4-Amino-2-methyl butane-2-ol can be employed as a research tool in chemical laboratories to study the reactivity and properties of amino alcohols. It can be used to investigate the effects of structural modifications on the reactivity and selectivity of chemical reactions, as well as to explore new synthetic routes and methodologies.

Synthesis Reference(s)

Journal of the American Chemical Society, 115, p. 7250, 1993 DOI: 10.1021/ja00069a025

Upstream product

• 13822-06-5 3,3-dimethylallylamine 
• 13635-04-6 3-hydroxy-3-methylbutyronitrile 
• 13157-54-5 2,6,6-trimethyl-5,6-dihydro-4H-[1,3]oxazine 
• 7664-93-9 sulfuric acid 
• 107-85-7 1-amino-3-methylbutane 
• 2568-33-4 3-methyl-butane-1,3-diol 
• 135859-47-1 3-hydroxy-3-methylbutyl methanesulfonate 
• 876732-44-4 4-azido-2-methylbutan-2-ol 

Downstream Products

• 910377-29-6 2-methyl-4-[(2-nitrophenyl)amino]-2-butanol 
• 1061668-07-2 4-{4-[2-(2,4-difluorophenyl)-8-methylimidazo[1,2-a]pyrazin-3-yl]-pyrimidin-2-ylamino}-2-methyl-butan-2-ol 
• 946849-78-1 carbonic acid 3-(9H-fluoren-9-ylmethoxycarbonylamino)-1,1-dimethyl-propyl ester 4-nitro-phenyl ester 
• 840491-22-7 6-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]pyridazine-3-carboxylic acid (3-hydroxy-3-methylbutyl)amide 
• 1428631-24-6 5-((3-fluorophenyl)ethynyl)-N-(3-hydroxy-3-methylbutyl)picolinamide 
• 34021-60-8 N-(3-hydroxy-3-methylbutyl)benzamide 
• 1289647-99-9 C₂₃H₂₂F₃N₃O₃ 

Relevant academic research and scientific papers

Chemoenzymatic enrichment of phosphotyrosine-containing peptides

(Chemical Equation Presented) Change the Tyr: A tyrosinase-assisted chemoenzymatic method was used to modify and enrich phosphotyrosine-containing peptides from a peptide mixture. This approach could be used to study protein tyrosine phosphorylation, and represents a promising alternative to immunoaffinity purification by using antiphosphotyrosine antibodies.

CONDENSED AZACYCLES AS SIGMA LIGAND COMPOUNDS AND USES THEREOF

The present disclosure relates to compounds of Formula (I) and their prodrugs, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods of their preparation. The compounds disclosed herein are useful for modulating Sigma receptors and have antiviral activity, and may also be useful in the treatment and/or prevention of pain disorders, neurological disorders (e.g., Parkinson's disease and Alzheimer's disease), and cancer.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Remote C(sp3)-H Oxygenation of Protonated Aliphatic Amines with Potassium Persulfate

This letter describes the development of a method for selective remote C(sp3)-H oxygenation of protonated aliphatic amines using aqueous potassium persulfate. Protonation serves to deactivate the proximal C(sp3)-H bonds of the amine substrates and also renders the amines soluble in the aqueous medium. These reactions proceed under relatively mild conditions (within 2 h at 80 °C with amine as limiting reagent) and do not require a transition metal catalyst. This method is applicable to a variety of types of C(sp3)-H bonds, including 3°, 2°, and benzylic C-H sites in primary, secondary, and tertiary amine substrates.

HETEROARYL SULFONAMIDE COMPOUND OR SALT THEREOF

PROBLEM TO BE SOLVED: To provide a novel herbicide. SOLUTION: The present invention provides a heteroaryl sulfonamide compound of the general formula (I) or a salt thereof, and a herbicide containing the compound as an active ingredient. [In the formula, A is O, S, SO, SO2 or CR8R9; W is O or S; Z is O, S or CR10R11; m and n are 0, 1 or 2 and satisfy 0≤n+m≤3; q is 0, 1, or 2; R1 is halo C1-C6 alkyl; R2 is H or C1-C12 alkoxycarbonyl; R3 is a halogen atom, optionally halo-substituted C1-C6 alkyl, C2-C6 alkenyl, alkynyl, C3-C6 cycloalkyl, C1-C6 alkylsulfonyl, or the like.] COPYRIGHT: (C)2015,JPOandINPIT

Isotope-coded chemical reporter and acid-cleavable affinity reagents for monitoring protein sulfenic acids

We have developed an approach that allows relative quantification of protein sulfenic acids using a pair of light and heavy isotope labled probes, DAz-2 and d6-DAz-2. In conjunction with a new complementary acid-cleavable linker, Yn-ACL, we dem

Synthesis and characterization of a 'fluorous' (fluorinated alkyl) affinity reagent that labels primary amine groups in proteins/peptides

Strong non-covalent interactions such as biotin-avidin affinity play critical roles in protein/peptide purification. A new type of 'fluorous' (fluorinated alkyl) affinity approach has gained popularity due especially to its low level of non-specific binding to proteins/peptides. We have developed a novel water-soluble fluorous labeling reagent that is reactive (via an active sulfo-N-hydroxylsuccinimidyl ester group) to primary amine groups in proteins/peptides. After fluorous affinity purification, the bulky fluorous tag moiety and the long oligoethylene glycol (OEG) spacer of this labeling reagent can be trimmed via the cleavage of an acid labile linker. Upon collision-induced dissociation, the labeled peptide ion yields a characteristic fragment that can be retrieved from the residual portion of the fluorous affinity tag, and this fragment ion can serve as a marker to indicate that the relevant peptide has been successfully labeled. As a proof of principle, the newly synthesized fluorous labeling reagent was evaluated for peptide/protein labeling ability in phosphate-buffered saline (PBS). Results show that both the aqueous environment protein/peptide labeling and the affinity enrichment/separation process were highly efficient.

BENZIMIDAZOLONE DERIVATIVES

This invention relates to compounds and methods for the treatment of a condition mediated by CB1 receptor activity in a mammalian subject including a human, which comprises administering to a mammal in need of such treatment a therapeutically effective am

BENZIMIDAZOLONE DERIVATIVES AS CB2 RECEPTOR LIGANDS

This invention relates to compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein: A, B, R1, R2 and R3 are each as described herein, and compositions containing such compounds and the use of suc

2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS

Substituted heteroaryl nitrile derivatives of Formula (I) processes for their preparation, pharmaceutical compositions comprising such compounds and use of the compounds as cysteine protease inhibitors are provided.