267405-89-0Relevant academic research and scientific papers
Amide and diamide inhibitors of IMPDH enzyme for use in treating IMPDH-associated disorders
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, (2008/06/13)
The present invention discloses the identification of the inhibitors of IMPDH (inosine-5′-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH associated disorders, such as transplant rejection and autoimmune diseases.
Novel diamide-based inhibitors of IMPDH
Gu, Henry H.,Iwanowicz, Edwin J.,Guo, Junqing,Watterson, Scott H.,Shen, Zhongqi,Pitts, William J.,Dhar,Fleener, Catherine A.,Rouleau, Katherine,Sherbina,Witmer, Mark,Tredup, Jeffrey,Hollenbaugh, Diane
, p. 1323 - 1326 (2007/10/03)
A series of novel amide-based small molecule inhibitors of inosine monophosphate dehydrogenase is described. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are presented.
