267411-98-3

Upstream product

• 1774-47-6 trimethylsulfoxonium iodide 

Downstream Products

• 216481-88-8 (+)-cis-2-amino-6-chloro-9-<(4'R)-(hydroxymethyl)cyclopent-2'-en-(1'S)-yl>purine 
• 124915-24-8 (+)-carbovir 
• 159163-56-1 9-((1S,4R)-4-Benzyloxymethyl-cyclopent-2-enyl)-9H-purin-6-ylamine 
• 159163-55-0 9-((1S,4R)-4-Benzyloxymethyl-cyclopent-2-enyl)-6-chloro-9H-purin-2-ylamine 
• 261511-22-2 (1S)-cis-4-Benzyloxymethylcyclopent-2-en-1-ol 
• 934986-74-0 (1R,4R)-4-(benzyloxymethyl)cyclopent-2-enol 
• 267411-97-2 Carbonic acid (1S,4R)-4-benzyloxymethyl-cyclopent-2-enyl ester ethyl ester 
• 267411-96-1 (4S,5R)-3-((1S,2R)-2-Benzyloxymethyl-4-oxo-cyclopentyl)-4,5-diphenyl-oxazolidin-2-one 
• 267411-95-0 (4S,5R)-3-((S)-2-Benzyloxymethyl-4-oxo-cyclopent-2-enyl)-4,5-diphenyl-oxazolidin-2-one 

Relevant academic research and scientific papers

A Novel, One-Pot Ring Expansion of Cyclobutanones. Syntheses of Carbovir and Aristeromycin

A novel, one-pot ring-expansion procedure was developed using Me3S(O)I, NaH, and Sc(OTf)3. The scope and limitations were briefly examined, and a tentative mechanism was proposed. Application of the methodology to known cyclobutanone 1 provided the corresponding cyclopentanone, which was successfully advanced to (+)-carbovir and (+)-aristeromycin.