267416-81-9

Basic information

• Product Name: 5-AMINO-2-(PHENOXY)BENZOTRIFLUORIDE
• Synonyms: 4-PHENOXY-3-TRIFLUOROMETHYLANILINE;4-PHENOXY-3-(TRIFLUOROMETHYL)PHENYLAMINE;5-AMINO-2-(PHENOXY)BENZOTRIFLUORIDE;5-Amino-2-(phenoxy)benzotrifluoride 98%;5-Amino-2-(phenoxy)benzotrifluoride98%;4-Phenoxy-3-(trifluoromethyl)aniline 98%;5-Amino-2-phenoxybenzotrifluoride, 4-Amino-2-(trifluoromethyl)diphenyl ether;4-Phenoxy-3-(trifluoromethyl)aniline98%
• CAS NO: 267416-81-9
• Molecular Formula: C13H10F3NO
• Molecular Weight: 253.22
• Mol File: 267416-81-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 55-57°C
• Boiling Point: 311.7 °C at 760 mmHg
• Flash Point: 142.3 °C
• Appearance: /
• Density: 1.293 g/cm³
• Vapor Pressure: 0.000555mmHg at 25°C
• Refractive Index: 1.545
• CAS DataBase Reference: 5-AMINO-2-(PHENOXY)BENZOTRIFLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-2-(PHENOXY)BENZOTRIFLUORIDE(267416-81-9)
• EPA Substance Registry System: 5-AMINO-2-(PHENOXY)BENZOTRIFLUORIDE(267416-81-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 267416-81-9(Hazardous Substances Data)

Usage

General Description

5-AMINO-2-(PHENOXY)BENZOTRIFLUORIDE is an organic compound that belongs to the class of benzenesulfonamides. It is a white solid at room temperature with a molecular formula of C13H10F3NO. This chemical is primarily used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also used as a reagent in organic synthesis, particularly in the preparation of heterocyclic compounds. 5-AMINO-2-(PHENOXY)BENZOTRIFLUORIDE is known for its strong electron-withdrawing properties due to the presence of the trifluoromethyl group, making it a versatile compound for various chemical reactions and applications in the field of organic chemistry.

InChI:InChI=1/C13H10F3NO/c14-13(15,16)11-8-9(17)6-7-12(11)18-10-4-2-1-3-5-10/h1-8H,17H2

Upstream product

• 108-95-2 phenol 
• 6969-95-5 4-phenoxy3-trifluoromethylnitrobenzene 
• 400-74-8 2-Fluoro-5-nitrobenzotrifluoride 

Relevant articles and documents

Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents

Hypertension is an important target for drug discovery. We have focused on the with-no-lysine kinase (WNK)-oxidative stress-responsive 1 (OSR1) and STE20/SPS1-related proline-alanine-rich protein kinase (SPAK)-NaCl cotransporter (NCC) signal cascade as a potential target, and we previously developed a screening system for inhibitors of WNK-OSR1/SPAK-NCC signaling. Herein we used this system to examine the structure-activity relationship (SAR) of salicylanilide derivatives as SPAK kinase inhibitors. Structural design and development based on our previous hit compound, aryloxybenzanilide derivative 2, and the veterinary anthelmintic closantel (3) led to the discovery of compound 10 a as a potent SPAK inhibitor with reduced toxicity. Compound 10 a decreased the phosphorylation level of NCC in mouse kidney in vivo, and appears to be a promising lead compound for a new class of antihypertensive drugs.

Substituted bicyclic derivatives useful as anticancer agents

The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R1, R3and R4are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals with administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.