26744-15-0

Basic information

• Product Name: (2R)-2-[(4-METHOXYPHENOXY)METHYL]OXIRANE
• Synonyms: (R)-4-METHOXYPHENYL GLYCIDYL ETHER;(2R)-2-[(4-METHOXYPHENOXY)METHYL]OXIRANE
• CAS NO: 26744-15-0
• Molecular Formula: C10H12O3
• Molecular Weight: 180.2
• Mol File: 26744-15-0.mol
• Article Data: 60

Chemical Properties

• Boiling Point: 287.9 °C at 760 mmHg
• Flash Point: 95.5 °C
• Appearance: /
• Density: 1.142 g/cm³
• CAS DataBase Reference: (2R)-2-[(4-METHOXYPHENOXY)METHYL]OXIRANE(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-[(4-METHOXYPHENOXY)METHYL]OXIRANE(26744-15-0)
• EPA Substance Registry System: (2R)-2-[(4-METHOXYPHENOXY)METHYL]OXIRANE(26744-15-0)

Safety Data

• Hazardous Substances Data: 26744-15-0(Hazardous Substances Data)

Usage

General Description

(2R)-2-[(4-Methoxyphenoxy)methyl]oxirane is a chemical compound that belongs to the class of epoxides. It contains a 2R stereochemistry and consists of a three-membered ring with an oxygen atom. The compound is characterized by the presence of a methoxy group and a phenoxy group attached to a 2-carbon chain, which is in turn part of the oxirane ring. This chemical is used in various industrial and research applications, including as a reagent for organic synthesis and as a building block for the production of pharmaceuticals and agrochemicals. Its unique structure and properties make it a valuable tool in the development of new compounds and materials.

Upstream product

• 13391-35-0 allyl (4-methoxyphenyl) ether 
• 150-76-5 4-methoxy-phenol 
• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 51594-55-9 (R)-(-)-epichlorohydrin 
• 141987-52-2 Acetic acid (S)-1-chloromethyl-2-(4-methoxy-phenoxy)-ethyl ester 
• 106-89-8 epichlorohydrin 
• 130998-33-3 (2R/S,4S)-4-(4-methoxyphenyl)-2-phenyl-1,3-dioxolane 
• 25772-85-4 (+/-)-1-chloro-3-(4-methoxyphenyloxy)-2-propanol 
• 213531-26-1 (S)-4-(4-Methoxy-phenoxymethyl)-[1,3,2]dioxathiolane 2-oxide 
• 17131-52-1 (R)-3-(p-methoxyphenoxy)-1,2-propanediol 
• 60456-23-7 (S)-oxiranemethanol 
• 130998-35-5 Toluene-4-sulfonic acid (S)-2-hydroxy-3-(4-methoxy-phenoxy)-propyl ester 
• 67843-74-7 (S)-epichlorohydrin 
• 2211-94-1 2,3-epoxypropyl p-methoxyphenyl ether 

Downstream Products

• 1414941-74-4 1-(4-methoxyphenoxy)-3-[4-[3-(3-pyridyl)-2-pyridyl]piperazin-1-yl]propan-2-ol 
• 1414941-75-5 1-(4-methoxyphenoxy)-3-[4-[3-(4-pyridyl)-2-pyridyl]piperazin-1-yl]propan-2-ol 
• 1414941-73-3 1-(4-methoxyphenoxy)-3-[4-[3-(2-pyridyl)-2-pyridyl]piperazin-1-yl]propan-2-ol 
• 1607802-83-4 1-(4-methoxyphenoxy)-3-[4-[2-(3-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol 
• 1607802-84-5 1-(4-methoxyphenoxy)-3-[4-[2-(4-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol 
• 1607802-82-3 1-(4-methoxyphenoxy)-3-[4-[2-(2-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol 
• 1607802-86-7 (R)-1-(4-methoxyphenoxy)-3-[4-[2-(4-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol 
• 1607802-87-8 (S)-1-(4-methoxyphenoxy)-3-[4-[2-(4-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol 

Relevant articles and documents

Design, synthesis and biological evaluation of imidazole and triazole-based carbamates as novel aromatase inhibitors

In the search for novel aromatase inhibitors, a series of triazole and imidazole-based carbamate derivatives were designed and synthesized. Final compounds were thus evaluated against human aromatase by in vitro kinetic experiments in a fluorimetric assay in comparison with letrozole. The effect of most active derivatives 13a and 15c was then evaluated in vitro on the human breast cancer cell line MCF7 by MTT assay, cytotoxicity assay (LDH release) and cell cycle analysis, revealing a dose-dependent inhibition profile of cell viability and low micromolar IC50 values. In addition, docking simulations were also carried out to elucidate at a molecular level of detail the binding modes adopted to target human aromatase.

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Engineering a homochiral metal-organic framework based on an amino acid for enantioselective separation

A chiral metal-organic framework possessing an open amphiphilic channel is constructed from a dicarboxylate ligand derived from an amino acid and is shown to be an efficient and recyclable chiral solid adsorbent, which is capable of separating racemic secondary alcohols, epoxides, and ibuprofen with very high enantioselectivity.