26751-04-2 Usage
Description
2-Hydroxy-3-methoxybenzamide is an organic compound with the chemical formula C8H9NO3. It is a derivative of benzamide, which is a type of amide derived from benzoic acid. 2-HYDROXY-3-METHOXYBENZAMIDE is characterized by the presence of a hydroxyl group (-OH) at the 2nd position and a methoxy group (-OCH3) at the 3rd position on the benzene ring, with an amide group (-CONH2) attached to the 1st position.
Uses
Used in Pharmaceutical Industry:
2-Hydroxy-3-methoxybenzamide is used as a key intermediate in the synthesis of various benzamide, benzoxazinone, benzothiazinone, and quinazolinone derivatives. These derivatives have potential applications in the prevention and treatment of diseases associated with poly(ADP-ribose) polymerase-1 (PARP-1). PARP-1 is an enzyme involved in DNA repair and regulation of gene expression, and its inhibition has been shown to have therapeutic effects in various diseases, including cancer and neurodegenerative disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 26751-04-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,7,5 and 1 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 26751-04:
(7*2)+(6*6)+(5*7)+(4*5)+(3*1)+(2*0)+(1*4)=112
112 % 10 = 2
So 26751-04-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO3/c1-12-6-4-2-3-5(7(6)10)8(9)11/h2-4,10H,1H3,(H2,9,11)
26751-04-2Relevant articles and documents
Pharmaceutical composition for use in preventing or treating poly(ADP-ribose)polymerase-1 related diseases containing the same as an active ingredient
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, (2018/06/29)
The present invention relates to a novel compound, a method for manufacturing the same, and a pharmaceutical composition for preventing or treating poly(ADP-ribose)polymerase-1 (PARP-1) related diseases containing the compound as an active ingredient. The novel PARP-1 inhibitory compound according to the present invention exhibits an excellent PARP-1 inhibitory effect at a concentration of nanomol unit and further exhibits an excellent cytoprotective effect (cell death inhibitory effect) on ophthalmic diseases or disorders, especially on retinal diseases. The composition containing the compound as an active ingredient is useful as a composition for preventing or treating PARP-1 related diseases, for example, ophthalmic diseases or disorders.(AA) Example 37(BB) Example 39COPYRIGHT KIPO 2018
PARP inhibitors
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Page/Page column 25-26, (2008/06/13)
A compound of the formula (I): and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R2, R3, R4 and R5 are independently selected from the group consisting of H, C1-7 /su
