267641-97-4Relevant articles and documents
Pyrazole analogues of prazosin
Ermondi, Giuseppe,Boschi, Donatella,Di Stilo, Antonella,Tironi, Carla,Gasco, Alberto
, p. 519 - 524 (1998)
A series of analogues of prazosin, in which 1-methyl or 1- phenylpyrazole moieties were substituted for the furan ring, were synthesized and studied for their α1-adrenoceptor antagonist activity. The role of the five member heterocyclic substru
A novel series of potent and selective small molecule inhibitors of the complement component C1s
Subasinghe, Nalin L.,Ali, Farah,Illig, Carl R.,Rudolph, M. Jonathan,Klein, Scott,Khalil, Ehab,Soll, Richard M.,Bone, Roger F.,Spurlino, John C.,DesJarlais, Renee L.,Crysler, Carl S.,Cummings, Maxwell D.,Morris Jr., Philip E.,Kilpatrick, John M.,Babu, Y. Sudhakara
, p. 3043 - 3047 (2007/10/03)
Activation of the classical pathway of complement has been implicated in disease states such as hereditary angioedema, ischemia-reperfusion injury and acute transplant rejection. The trypsin-like serine protease C1s represents a pivotal upstream point of
The Direct Carboxylation of Pyrazoles
Chiriac, C. I.
, p. 753 - 755 (2007/10/02)
Various pyrazole-4-carboxylic acids 4 were obtained by a direct carboxylation reaction of pyrazoles 1 with excess, oxalyl chloride.
