267666-09-1

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(2-Nitro-benzenesulfonyl)-piperidin-4-one is used as a key intermediate for the synthesis of various pharmaceuticals. Its unique chemical structure, which includes a piperidin-4-one ring and reactive nitro and sulfonyl groups, allows for the creation of a broad spectrum of medicinal compounds with different therapeutic applications.
Used in Organic Synthesis:
In the field of organic chemistry, 1-(2-Nitro-benzenesulfonyl)-piperidin-4-one is utilized as a versatile building block for the synthesis of a diverse array of organic compounds. Its reactivity and unique structural features make it an indispensable component in the development of novel organic molecules with potential applications in various industries, such as materials science, agrochemicals, and specialty chemicals.
Used in Chemical Research:
1-(2-Nitro-benzenesulfonyl)-piperidin-4-one is also employed as a valuable research tool in chemical laboratories. Its unique properties and reactivity make it an ideal candidate for studying various chemical reactions and mechanisms, contributing to the advancement of knowledge in organic chemistry and related fields.

Upstream product

• 41979-39-9 4-piperidone hydrochloride 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 

Downstream Products

• 958741-23-6 4,4-dimethoxy-1-(2-nitro-benzenesulfonyl)-piperidine 
• 41661-47-6 piperidin-4-one 
• 1323264-42-1 4-tert-butoxycarbonylamino-1-[6-tert-butoxycarbonylamino-4-([{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridin-2-yl]methyl)]piperidine 
• 1323264-39-6 [6-tert-butoxycarbonylamino-4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2-yl]methanol 
• 1323264-37-4 methyl 6-tert-butoxycarbonylamino-4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2-carboxylate 
• 1323264-35-2 6-methoxycarbonyl-4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2-carboxylic acid 
• 1323264-34-1 dimethyl 4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2,6-dicarboxylate 
• 1323264-51-2 N-(1-[{6-amino-4-[(1-propylpiperidin-4-yl)methyl]pyridin-2-yl}methyl]piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenylacetamide 
• 1323264-48-7 4-methylene-1-(2-nitrophenylsulfonyl)piperidine 
• 267666-44-4 trifluoromethanesulfonic acid 5-benzenesulfonyl-7-methoxy-2-(2-nitrobenzenesulfonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl ester 
• 267666-28-4 5-benzenesulfonyl-8-hydroxy-7-methoxy-2-(2-nitrobenzensulfonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 267666-38-6 5-benzenesulfonyl-7,8-dimethoxy-2-(2-nitrobenzenesulfonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 267666-15-9 4-methoxy-1-(2-nitro-benzenesulfonyl)-1,2,3,6-tetrahydro-pyridine 

Relevant academic research and scientific papers

THERAPEUTICS TARGETING TRUNCATED ADENOMATOUS POLYPOSIS COLI (APC) PROTEINS

The described invention provides small molecule anti-cancer compounds that selectively target and inhibit measurable biological activity of truncated APC proteins, an immortalized Human Colonic Epithelial Cell (HCEC) model, and pharmaceutical compositions comprising at least one of the small molecule anti-cancer compounds and a pharmaceutically acceptable carrier.

Lewis Acid-Directed Cyclocondensation of Piperidone Enol Ethers with 2-Methoxy-4-(N-phenylsulfonyl)-1,4-benzoquinoneimine: A New Regioselective Synthesis of Oxygenated Carbolines

Lewis acid-directed cyclocondensations of piperidone enol ethers with 2-methoxy-4-(N-phenylsulfonyl)-1,4-henzoquinoneimine are reported. Benzofurans are obtained with BF3·OEt2 as a promoter, whereas use of excess amounts of TiCl4:Ti(OiPr)4 leads to tetrahydrocarbolines. The latter reactions provide expedient routes to oxygen-substituted tetrahydrocarbolines and carbolines. As applications of this new methodology, the preparations of 1-[3-(dimethylamino)propyl]amino-7-methoxy- and 1-[3-(dimethylamino)propyl]amino-7,8-dimethoxy-5H-pyrido[4,3-b]indoles are described.