267666-39-7

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 1027657-45-9 1-benzenesulfonyl-3,3-dimethoxy-piperidine 
• 267666-10-4 N-benzenesulfonyl-3-piperidone 
• 196883-02-0 2,9-bis-benzenesulfonyl-7-methoxy-2,3,4,9-tetrahydro-1H-β-carbolin-6-ol 
• 74-88-4 methyl iodide 

Downstream Products

• 267666-56-8 9-benzenesulfonyl-6,7-dimethoxy-9H-β-carboline 

Relevant academic research and scientific papers

Lewis Acid-Directed Cyclocondensation of Piperidone Enol Ethers with 2-Methoxy-4-(N-phenylsulfonyl)-1,4-benzoquinoneimine: A New Regioselective Synthesis of Oxygenated Carbolines

Lewis acid-directed cyclocondensations of piperidone enol ethers with 2-methoxy-4-(N-phenylsulfonyl)-1,4-henzoquinoneimine are reported. Benzofurans are obtained with BF3·OEt2 as a promoter, whereas use of excess amounts of TiCl4:Ti(OiPr)4 leads to tetrahydrocarbolines. The latter reactions provide expedient routes to oxygen-substituted tetrahydrocarbolines and carbolines. As applications of this new methodology, the preparations of 1-[3-(dimethylamino)propyl]amino-7-methoxy- and 1-[3-(dimethylamino)propyl]amino-7,8-dimethoxy-5H-pyrido[4,3-b]indoles are described.