267875-65-0

Basic information

• Product Name: 2,2-DIFLUORO-2-PYRIDIN-2-YLETHANOL
• Synonyms: 2,2-DIFLUORO-2-PYRIDIN-2-YLETHANOL;2,2-Difluoro-2-(2-pyridyl)ethan-1-ol;2,2-Difluoro-2-(pyridin-2...;2-Pyridineethanol, b,b-difluoro-;2,2-Difluoro-2-(2-pyridyl)ethanol
• CAS NO: 267875-65-0
• Molecular Formula: C₇H₇F₂NO
• Molecular Weight: 159.1333864
• Mol File: 267875-65-0.mol

Chemical Properties

• Boiling Point: 255℃
• Flash Point: 108℃
• Appearance: /
• Density: 1.275
• Vapor Pressure: 0.009mmHg at 25°C
• Refractive Index: 1.478
• PKA: 13.31±0.10(Predicted)
• CAS DataBase Reference: 2,2-DIFLUORO-2-PYRIDIN-2-YLETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIFLUORO-2-PYRIDIN-2-YLETHANOL(267875-65-0)
• EPA Substance Registry System: 2,2-DIFLUORO-2-PYRIDIN-2-YLETHANOL(267875-65-0)

Safety Data

• Hazardous Substances Data: 267875-65-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,2-Difluoro-2-pyridin-2-ylethanol is used as a key intermediate for the synthesis of various pharmaceuticals. Its incorporation of fluorine atoms into drug molecules can enhance their pharmacokinetic and pharmacodynamic properties, such as lipophilicity, metabolic stability, and bioavailability, thereby improving the overall efficacy and safety of the drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 2,2-Difluoro-2-pyridin-2-ylethanol serves as a building block for the production of fluorine-containing pesticides. The introduction of fluorine atoms can significantly increase the pesticidal activity and selectivity, leading to more effective and environmentally friendly agrochemicals.
Used in Specialty Chemicals Industry:
2,2-Difluoro-2-pyridin-2-ylethanol is also utilized in the synthesis of specialty chemicals, where its unique properties can be leveraged to create novel compounds with specific applications in various fields, such as materials science, coatings, and dyes.
Used as a Solvent in Chemical Reactions:
2,2-DIFLUORO-2-PYRIDIN-2-YLETHANOL is employed as a solvent in various chemical reactions, providing a suitable medium for the reactions to occur. Its properties may contribute to the efficiency and selectivity of the reactions, facilitating the synthesis of desired products.
Used as a Reagent in Organic Transformations:
2,2-Difluoro-2-pyridin-2-ylethanol is used as a reagent in a range of organic transformations, where it can participate in reactions such as nucleophilic substitutions, addition reactions, and rearrangements. Its presence can influence the outcome of these reactions, enabling the formation of specific products with desired characteristics.

InChI:InChI=1/C7H7F2NO/c8-7(9,5-11)6-3-1-2-4-10-6/h1-4,11H,5H2

Upstream product

• 267876-28-8 ethyl 2,2-difluoro-2-(pyridin-2-yl)acetate 
• 55104-63-7 ethyl 2-(pyridin-2-yl)-2-oxoacetate 
• 109-04-6 2-bromo-pyridine 
• 2739-98-2 ethyl 2-(pyridinyl-2)acetate 

Downstream Products

• 267875-68-3 2.2-Difluoro-2-(pyridin-2-yl)ethylamine 
• 435345-04-3 2,2-difluoro-2-(2-pyridyl)ethylamine benzenesulfonic acid salt 
• 1299945-50-8 2,2-difluoro-2-pyridin-2-ylethyl 4-methylbenzenesulfonate 

Relevant articles and documents

Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines

Recent efforts in the field of thrombin inhibitor research have focused on the identification of compounds with good oral bioavailability and pharmacokinetics. In this manuscript we describe a metabolism-based approach to the optimization of the 3-(2-phen

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An effective preparative approach to fluorinated pyridinylacetonitriles, based on electrophilic fluorination of pyridinylacetonitriles, was developed. Their synthetic potential for obtaining new fluorine-containing building blocks and heterocyclic systems was disclosed.

PYRROLOPYRIMIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS

Disclosed are chemical entities of formula I: [INSERT CHEMICAL FORMULA HERE] wherein X, Y, Z, R1, R3, R4, R5 and R6 are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of formula I, and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of formula I.

DIFLUOROETHYLPYRIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS

Disclosed are chemical entities of formula (I) wherein X, Y, Z, R1, R3, R4, R5 and R6 are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of formula (I), and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of formula I.

Practical selective hydrogenation of α-fluorinated esters with bifunctional pincer-type ruthenium(II) catalysts leading to fluorinated alcohols or fluoral hemiacetals

Selective hydrogenation of fluorinated esters with pincer-type bifunctional catalysts RuHCl(CO)(dpa) 1a, trans-RuH2(CO)(dpa) 1b, and trans-RuCl2(CO)(dpa) 1c under mild conditions proceeds rapidly to give the corresponding fluorinated alcohols or hemiacetals in good to excellent yields. Under the optimized conditions, the hydrogenation of chiral (R)-2-fluoropropionate proceeds smoothly to give the corresponding chiral alcohol without any serious decrease of the ee value.

METHOD FOR PRODUCING -FLUOROALCOHOL

A production method of a β-fluoroalcohol includes performing a reaction of an α-fluoroester with hydrogen gas (H2) in the presence of a specific ruthenium complex (i.e. a ruthenium complex of the general formula [2], preferably a ruthenium complex of the general formula [4]). This production method can employ a suitable hydrogen pressure of 1 MPa or less by the use of such a specific ruthenium complex and does not require a high-pressure gas production facility when put in industrial practice. In addition, this production method can remarkably reduce the amount of catalyst used therein (to e.g. a substrate/catalyst ratio of 20,000) in comparison to the substrate/catalyst ratio conventional reduction of α-fluoroalcohol. It is possible by these reduction in hydrogen pressure and catalyst amount to largely reduce the production cost of the β-fluoroalcohol.

2,6-Diaminopyridine Compounds Suitable For Treating Diseases Associated With Amyloid Or Amyloid-Like Proteins Or For Treating Or Preventing Ocular Diseases Or Conditions Associated With A Pathological Abnormality/Change In The Tissue Of The Visual System

The present invention relates to 2,6-diaminopyridine compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system.

2,6-Diaminopyridine compounds for treating diseases associated with amyloid proteins or for treating ocular diseases

The present invention relates to 2,6-diaminopyridine compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein and of diseases or conditions associated with amyloid-like proteins. The compoun

2,6-DIAMINOPYRIDINE COMPOUNDS SUITABLE FOR TREATING DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS OR FOR TREATING OR PREVENTING OCULAR DISEASES OR CONDITIONS ASSOCIATED WITH A PATHOLOGICAL ABNORMALITY/CHANGE IN THE TISSUE OF THE VISUAL SYSTEM

The present invention relates to 2.6-diaminopyridine compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein and of diseases or conditions associated with amyloid-like proteins. The compoun

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