55104-63-7

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 2-PYRIDINEGLYOXYLATE is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of complex compounds that possess medicinal properties.
Used in Agrochemical Industry:
In the agrochemical sector, ETHYL 2-PYRIDINEGLYOXYLATE is utilized as an intermediate in the production of agrochemicals, playing a crucial role in the synthesis of compounds that can enhance agricultural productivity and protect crops.
Used in Research and Development:
ETHYL 2-PYRIDINEGLYOXYLATE is employed in research and development as a chemical with potential medicinal and agricultural properties, allowing scientists to explore its applications and further understand its capabilities in creating new and effective compounds.

Upstream product

• 109-04-6 2-bromo-pyridine 
• 95-92-1 oxalic acid diethyl ester 
• 2739-98-2 ethyl 2-(pyridinyl-2)acetate 
• 2564-83-2 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical 
• 17997-47-6 2-tri-n-butylstannylpyridine 
• 4755-77-5 Ethyl oxalyl chloride 

Downstream Products

• 267876-28-8 ethyl 2,2-difluoro-2-(pyridin-2-yl)acetate 
• 93315-81-2 ethyl 3-phenylindolizine-1-carboxylate 
• 435345-04-3 2,2-difluoro-2-(2-pyridyl)ethylamine benzenesulfonic acid salt 
• 267875-65-0 2,2-difluoro-2-(pyridin-2-yl)-ethan-1-ol 
• 267875-68-3 2.2-Difluoro-2-(pyridin-2-yl)ethylamine 
• 39684-46-3 (E)-2-(methoxyimino)-2-phenylacetic acid 

Relevant academic research and scientific papers

Cobalt(II)-based Metalloradical Activation of 2-(Diazomethyl)pyridines for Radical Transannulation and Cyclopropanation

A new catalytic method for the denitrogenative transannulation/cyclopropanation of in-situ-generated 2-(diazomethyl)pyridines is described using a cobalt-catalyzed radical-activation mechanism. The method takes advantage of the inherent properties of a CoIII-carbene radical intermediate and is the first report of denitrogenative transannulation/cyclopropanation by a radical-activation mechanism, which is supported by various control experiments. The synthetic benefits of the metalloradical approach are showcased with a short total synthesis of (±)-monomorine.

ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE

Substituted aryl and heteroaryl ether compounds of the Formula (I) and pharmaceutically acceptable salts thereof, wherein X, R 1, R 2, R 3, L, R 4, L 1, Q, and R 5 are as defined herein. These compounds and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-β receptor (LXRβ) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.

Iodine-catalyzed [3+2] cyclization of 2-pyridylesters and chalcones: metal-free approach for the synthesis of substituted indolizines

A transition metal-free iodine catalyzed synthesis of indolizine derivatives through [3+2] cyclization of 2-pyridylesters and chalcones has been described. The method is efficient to synthesize a variety of substituted indolizines including hetero aromati

Potassium N-iodo p-toluenesulfonamide (TsNIK, iodamine-T): A new reagent for the oxidation of hydrazones to diazo compounds

A new reagent for the oxidation of hydrazones to diazo compounds is described. N-Iodo p-toluenesulfonamide (TsNIK, iodamine-T) allows the preparation of α-diazoesters, α-diazoamides, α-diazoketones and α-diazophosphonates in good yield and in high purity after a simple extractive work-up. α-Diazoesters were also obtained in high yield from the corresponding ketones through a one-pot process of hydrazone formation/oxidation. Diazo compounds: N-Iodo p-toluenesulfonamide (TsNIK, iodamine-T), readily prepared from p-toluenesulfonamide and iodine in aqueous KOH, is a new reagent for the oxidation of hydrazones to diazo compounds in good yields and high purity (see scheme).

Development of a scaleable synthesis of a 3-aminopyrazinone acetamide thrombin inhibitor

A scaleable route to 2-{3-[(2,2-difluoro-2-(2-pyridyl)ethyl)-animo]-6- chloro-2-oxohydropyrazinyl}-N-(3-fluoro(2-pyridyl))-methyl]acetamide 1 is described in which various scaleup issues were addressed to provide a safe, efficient, and robust route for th

Synthesis of aryl α-keto esters via the rearrangement of aryl cyanohydrin carbonate esters

A facile synthesis of aryl α-keto esters is reported involving the rearrangement of aryl cyanohydrin carbonate esters induced by the α-carbanion to the nitrile group generated by LDA. However, under similar conditions, an o-benzyloxycyanohydrin carbonate ester rearranged via a domino reaction leading to 2-phenylbenzofuran-3-carboxylic acid.

Thrombin inhibitors

Compounds of the invention are useful in inhibiting thrombin and treating blood coagulation and cardiovascular disorders and have the following structure: wherein R3 is hydrogen or halogen, and u is N or CH.

Pyrazinone thrombin inhibitors

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, wherein A is

Pyrazinone thrombin inhibitors

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: A is ?wherein Y1and Y2are independently hydrogen, C1-4alkyl, C1-4alkoxy, FuHvC(CH2)0-1O—, wherein u and v are either 1 or 2, provided that when u is 1, v is 2, and when u is 2, v is 1, C3-7cycloalkyl, thio C1-4alkyl, C1-4sulfinylalkyl, C1-4sulfonylalkyl, halogen cyano, or trifluoromethyl, and wherein b is 0 or 1.

Pyrrolidine modulators of chemokine receptor activity

The present invention is directed to pyrrolidine compounds of the formula 1: (wherein R1, R2, R3, R4, R5, R6and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.