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Usage

Uses

Used in Pharmaceutical Industry:
N-ethyl-propiolamide is used as a solvent and in organic synthesis for the development of pharmaceutical compounds. Its properties as a colorless liquid with a pungent odor make it suitable for use in the synthesis of various drugs.
Used in Agrochemical Industry:
N-ethyl-propiolamide is used as a solvent and in the synthesis of agrochemicals, contributing to the development of pesticides and other agricultural chemicals. Its versatility as a solvent and its ability to be used in organic synthesis make it valuable in this industry.
Used in Coatings Industry:
N-ethyl-propiolamide is used as a solvent in the production of coatings, such as paints and varnishes. Its properties as a colorless liquid with a pungent odor make it suitable for use in the formulation of various types of coatings.
Used as an Intermediate in Organic Synthesis:
N-ethyl-propiolamide is used as an intermediate for the synthesis of other organic compounds. Its amide functional group and its ability to be used in organic synthesis make it a valuable component in the production of various organic compounds.

Upstream product

• 75-04-7 ethylamine 
• 922-67-8 propynoic acid methyl ester 
• 623-47-2 propynoic acid ethyl ester 

Relevant academic research and scientific papers

Alkynylboration Reaction Leading to Boron-Containing π-Extended cis-Stilbenes as a Highly Tunable Fluorophore

An unprecedented boron-containing fluorophore, π-extended cis-stilbene, obtained via alkynylboration reaction of alkynamide is reported. Boron-containing π-extended cis-stilbenes emit fluorescence with high quantum yields in the solid state and exhibit aggregation-induced emission enhancement. The broad substrate scope of the alkynylboration reaction offers facile access to electronically diverse structures, enabling fine-tuning of light absorption/emission characteristics. The boron-containing π-extended cis-stilbene with a diphenylamino group displays solvatofluorochromism via an intramolecular charge-transfer transition.

PROCESS FOR PREPARING N-H OR N-ALKYL 2-PROPYNAMIDE

Disclosed is a method for the synthesis of N—H or N-alkyl 2-propynamides useful as intermediate in the manufacture of pharmaceutically active ingredients.

PROCESS FOR PREPARING N-H OR N-ALKYL 2-PROPYNAMIDE

Disclosed is a method for the synthesis of N-H or N-alkyl 2-propynamides useful as intermediate in the manufacture of pharmaceutically active ingredients.

Antitumor agents 247. New 4-ethoxycarbonylethyl curcumin analogs as potential antiandrogenic agents

4-Ethoxycarbonylethyl curcumin (ECECur) (3) is a current drug candidate for the treatment of prostate cancer. Due to problems inherent in the tautomerism of ECECur, 4-fluoro-4-ethoxycarbonylethyl curcumin (4) and 4- ethoxycarbonylethylenyl curcumin (5) were designed and synthesized. These two target compounds and their synthetic intermediates (4-9) were evaluated for their inhibitory activity against androgen receptor transcription in LNCaP and PC-3 prostate cancer cell lines. While the enol-keto analogs showed varying anti-androgen potencies, the di-keto analogs showed no activity. Tetrahydropyranylation of the phenoxy groups had a positive impact on the anti-AR activity of 4-ethoxycarbonylethylenyl curcumin, but a negative impact on the activity of ECECur. With potent anti-AR activity, di-tetrapyranylated 4-ethoxycarbonylethylenyl curcumin (9), which exists in only one form, is a good drug lead for further structural modification. Based on the SAR information obtained from the above study, five new compounds were designed and subsequently synthesized. Among them, compound 10 was found to be the most potent anti-AR agent and is considered to be a promising drug candidate for the treatment of prostate cancer.