26820-73-5

Basic information

• Product Name: 3-NITRO-2-(1-PYRROLIDINYL)PYRIDINE
• Synonyms: 3-NITRO-2-(1-PYRROLIDINYL)PYRIDINE;3-Nitro-2-(pyrrolidin-1-yl)pyridine
• CAS NO: 26820-73-5
• Molecular Formula: C9H11N3O2
• Molecular Weight: 193.2
• Mol File: 26820-73-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 42 °C
• Boiling Point: 102°C 0,3mm
• Flash Point: 158.8°C
• Appearance: /
• Density: 1.296g/cm³
• Vapor Pressure: 9.44E-05mmHg at 25°C
• Refractive Index: 1.601
• PKA: 3.02±0.29(Predicted)
• CAS DataBase Reference: 3-NITRO-2-(1-PYRROLIDINYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-NITRO-2-(1-PYRROLIDINYL)PYRIDINE(26820-73-5)
• EPA Substance Registry System: 3-NITRO-2-(1-PYRROLIDINYL)PYRIDINE(26820-73-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 26820-73-5(Hazardous Substances Data)

Usage

General Description

3-NITRO-2-(1-PYRROLIDINYL)PYRIDINE is a chemical compound with a molecular formula C11H12N4O2. It is a nitro pyridine derivative with a pyrrolidine group attached to its second carbon atom. 3-NITRO-2-(1-PYRROLIDINYL)PYRIDINE is primarily used in the synthesis of pharmaceuticals and agrochemicals. Its nitro group makes it a nitroaromatic compound, which can be a potential source of environmental pollution and health hazards if not handled and disposed of properly. It is important to follow safety protocols and guidelines when working with 3-NITRO-2-(1-PYRROLIDINYL)PYRIDINE to minimize any potential risks and ensure safe handling and usage.

InChI:InChI=1/C9H11N3O2/c13-12(14)8-4-3-5-10-9(8)11-6-1-2-7-11/h3-5H,1-2,6-7H2

Upstream product

• 123-75-1 pyrrolidine 
• 1480-87-1 2-fluoro-3-nitropyridine 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 76893-44-2 3-nitropyridine-2-phenyl ether 

Downstream Products

• 5028-13-7 2-(pyrrolidin-1-yl)pyridin-3-amine 

Relevant articles and documents

2,2,2-Trifluoroethoxy Aromatic Heterocycles: Hydrolytically Stable Alternatives to Heteroaryl Chlorides

Herein we describe the 2,2,2-trifluoroethoxy group as an alternative leaving group for hydrolytically unstable heteroaryl chlorides. This group provides improved shelf stability by years while maintaining reactivity toward nucleophiles in SNAr

TYROSINE KINASE NON-RECEPTOR 1 (TNK1) INHIBITORS AND USES THEREOF

Provided herein is a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g, X11, X22, R11, R22, R33, R44, R55, R66, R77, R88, m, n) are as described herein. Compounds of Formula I, pharmaceutically acceptable salts thereof, pharmaceutical compositions of either of the foregoing, and combinations of any of the foregoing can be used to treat tyrosine kinase non- receptor 1 (TNK1)-mediated diseases, disorders and conditions.

A palladium nanoparticle-catalyzed aryl-amine coupling reaction: High performance of aryl and pyridyl chlorides as the coupling partner

Carbon nitride (CN)-supported nanosized palladium particles, Pd-CN, have been found to be an active catalyst system for the amination of aryl and pyridyl chloride moieties in the presence of dialkyl amine under mild reaction conditions. The recyclability study of the reaction shows the stable performance of the catalyst without a significant loss of catalytic activity for a couple of cycles.