26825-34-3

Upstream product

• 100-00-5 4-chlorobenzonitrile 
• 1121-60-4 pyridine-2-carbaldehyde 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 55643-92-0 2-[3-(4-chloro-phenyl)-4,5-dihydro-3H-[1,2,3]triazol-4-yl]-pyridine 
• 68090-22-2 1-(4-Chlorphenyl)-5-pyrid-2-yl-1,2,3-triazole 
• 635750-65-1 (η6-hexamethylbenzene) ruthenium(II)Cl[N-(2-pyridinylmethylene)-p-chlorophenylamine] PF6 
• 221366-90-1 ReCl₃(P(C₆H₅)3)(C₁₂H₉ClN₂) 
• 186594-24-1 mer-trichloro(triphenylphosphine oxide)(N-(4-chlorophenyl)-2-pyridinecarboxaldimine)rhenium(III) 
• 141823-28-1 (((CH₃)2CHC₆H₄CH₃)RuCl(C₅H₄NCHNC₆H₄Cl))⁽¹⁺⁾*ClO₄^(1-)=(((CH₃)2CHC₆H₄CH₃)RuCl(C₅H₄NCHNC₆H₄Cl))(ClO₄) 
• 27048-28-8 4-chloro-N-(pyridin-2-ylmethyl)aniline 

Relevant academic research and scientific papers

N,N-Chelate nickel(II) complexes bearing Schiff base ligands as efficient hydrogenation catalysts for amine synthesis

Five N, N-chelate nickel (II) complexes bearing N-(2-pyridinylmethylene)-benzylamine ligands with different substituent groups were synthesized in good yields. The nickel complexes exhibited prominent catalytic efficiency toward amine synthesis from nitro compounds by using NaBH4 or H2 as hydrogen source through two catalytic systems. Various amines with different substituents were obtained in moderate to excellent yields. All substrates with electron-donating and electron-withdrawing properties were tolerated in the two reduction systems. Given the efficient catalytic activity, broad substance scope, and mild reduction conditions, the nickel catalysts have potential applications in industrial production.

Ruthenium-cymene containing pyridine-derived aldiimine ligands: Synthesis, characterization and application in the transfer hydrogenation of aryl ketones and kinetics studies

Five electron-rich N[sbnd]N′?pyridylimine ligands, which form five-membered chelate ring when coordinate to a metal center, have been synthesized by the easily accessible condensation between 2-pyridinecarboxyaldhehyde and the corresponding substituted an

Diverse C-6 substituted 4-methyl-2-(2-, 3- and 4-pyridinyl)quinolines: synthesis, in vitro anticancer evaluation and in silico studies

A series of twelve 4-methyl-2-(2-, 3- and 4-pyridinyl)quinolines 7–9 was synthesized using modified Kametani reaction protocol and their in vitro cytotoxicity was tested against human cancer cell lines MCF-7, SKBR-3, PC3, HeLa, comparing with human dermis

Chloro-ruthenium complexes with carbonyl and N-(aryl)pyridine-2-aldimines as ancillary ligands. Synthesis, characterization and catalytic application in C-C cross-coupling of arylaldehydes with arylboronic acids

Reaction of N-(aryl)pyridine-2-aldimines (L-R, R = OCH3, CH 3, H, Cl and NO2) with [Ru(CO)2Cl 2]n in refluxing ethanol affords a group of complexes of type [Ru(L-R)(CO)2Cl2]. In these complexes the diimine ligands (L-R) are coordinated to the metal center as NN-donors forming five-membered chelate rings, the carbonyls are mutually cis and the two chlorides are trans. Crystal structure of [Ru(L-OCH3)(CO) 2Cl2] has been determined. All the complexes show characteristic 1H NMR signals, and in dichloromethane solution they display intense absorptions in the visible and ultraviolet regions. Cyclic voltammetry on the complexes shows an irreversible oxidation of the metal center within 1.15-1.23 V vs SCE, and reduction(s) of the diimine ligand within -0.70 to -0.96 V vs SCE. The [Ru(L-R)(CO)2Cl2] complexes efficiently catalyze cross-coupling of arylaldehydes with arylboronic acids yielding diaryl ketones.

Synthesis and evaluation of gold(III) complexes as efficient DNA binders and cytotoxic agents

In recent years, great interest has been focused on gold(III) complexes as cytotoxic and antitumor drugs. Recent studies demonstrated that simple bidentate or polydentate ligands containing nitrogen donor atoms may offer sufficient redox stabilization to produce viable Au(III) anticancer drug targets under physiologic conditions. So, we have synthesized square planer Au(III) complexes of type [Au(An)Clx]Cly and characterized them using UV-Vis absorption, C, H, N elemental analysis, FT-IR, LC-MS, 1H and 13C NMR spectroscopy. These compounds manifested significant cytotoxic properties in vitro for brine shrimp lethality bioassay. The metal complexes were screened for series of DNA binding activity using UV-Vis absorption titration, hydrodynamic measurement and thermal DNA denaturation study. The nucleolytic activity was performed on plasmid pUC19 DNA. The Michaelis-Menten kinetic studies were performed to evaluate rate of enhancement in metal complexes mediated DNA cleavage over the non-catalyzed DNA cleavage.

Synthesis of di-nitrogen Schiff base complexes of methyltrioxorhenium(VII) and their application in epoxidation with aqueous hydrogen peroxide as oxidant

Several di-nitrogen Schiff bases were synthesized through the condensation of 2-pyridinecarboxaldehyde with primary amines. The Schiff bases as ligands coordinated with methyltrioxorhenium (MTO) smoothly to afford the correspondent complexes which were characterized by IR, 1H NMR, 13C NMR, MS and elemental analysis. One of the complexes was analyzed by X-ray crystallography as well. The results revealed that the complexes display distorted octahedral geometry in the solid state with a trans-position of Schiff base. Catalytic results indicated that the complexes as catalysts increased the selectivity of epoxides remarkably compared with MTO in the epoxidation of alkenes with 30% hydrogen peroxide as oxidant and the increasing rate depended on the structure of the Schiff base ligands of the complexes. The results indicated that the stronger the donating ability of the ligand, the higher selectivity of epoxides the complex gave in the epoxidation of alkenes with 30% hydrogen peroxide as oxidant. Copyright

Synthesis and electrochemical studies of nickel -diketonate complexes incorporating asymmetric diimine ligands

The reaction of ppaX {(4-X-phenyl)-pyridin-2-ylmethylene-amine; X = H, Me, Et, OMe, F, Cl, Br, and I} with [Ni(β-diketonate) 2(H2O)2] {β-diketonate = 1,3-diphenylpropanedionate (dbm), 2,2,6,6-tetramethyl-3,5-hep

Multicomponent reaction of imidazo[1,5- a ]pyridine carbenes with aldehydes and dimethyl acetylenedicarboxylate or allenoates: A straightforward approach to fully substituted furans

The facile three-component reactions of N,N-substituted imidazo[1,5-a]pyridine carbenes, namely imidazo[1,5-a]pyridin-3-ylidenes, with aldehydes and DMAD or allenoates were disclosed. Both reactions proceeded via tandem nucleophilic addition, [3 + 2]-cycloaddition, and ring transformation to produce different 4-[(2-pyridyl)methyl]aminofuran derivatives generally in moderate yields. This work not only 'rovided the first example of the application of imidazo[1,5-a]pyridin-3-ylidenes in organic synthesis but also developed a straightforward approach to fully substituted furans that are not easily accessible by other methods.

Anil-Synthese. 22 Mitteilung. Ueber die Herstellung von Styryl und Distyryl-Derivaten des Pyridins

2,4-, 2,5- and 2,6-Dimethylpyridines react with anils of aromatic aldehydes in the presence of dimethylformamide and potassium hydroxide to yield the corresponding distyrylpyridines ('anil synthesis').Under the same reaction conditions (4-methylstyryl)pyridines are converted to (stilbenylvinyl)pyridines.Similarly, the Schiff's base derived from pyridine-3-carbaldehyde and chloranile on treatment with methyl- and p-tolyl-substituted aromatic hetericycles gives the corresponding (heteroaryl-styryl)pyridines, whereas with the Schiff's bases derived from pyridine-2= and -4-carbaldehyde side reactions, such as dimerization followed by disproportionation predominate.