26870-72-4

Usage

Chemical structure

A pyrimidine derivative containing a chlorophenyl group at position 2 and two chlorine atoms at positions 4 and 6

Uses

Synthesis of pharmaceuticals and agrochemicals, potential biological activities (anti-inflammatory and anti-cancer properties), building block in the pharmaceutical industry for creating new drug candidates

Importance

Significant in medicinal chemistry and drug discovery research

Upstream product

• 59541-08-1 2-(4-chloro-phenyl)-1H-pyrimidine-4,6-dione 
• 121-69-7 N,N-dimethyl-aniline 
• 83217-77-0 2-p-chlorophenyl-4,6-dihydroxypyrimidine 
• 14401-51-5 4-chlorobenzamidine hydrochloride 

Downstream Products

• 859208-43-8 4-chloro-2-(4-chloro-phenyl)-6-methoxy-pyrimidine 
• 856972-94-6 6-chloro-2-(4-chloro-phenyl)-pyrimidin-4-ylamine 
• 1394124-10-7 methyl 2-(2-(6-chloro-2-(4-chlorophenyl)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate 
• 1394124-11-8 (E)-methyl 2-(2-(6-chloro-2-(4-chlorophenyl)pyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate 
• 1394124-19-6 (E)-methyl 2-(2-(2-(4-chlorophenyl)-6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate 
• 552872-54-5 N-(2-{[6-Chloro-2-(4-chlorophenyl)pyrimidin-4-yl]amino}ethyl)acetamide 

Relevant academic research and scientific papers

Synthesis and antifungal activities of new type β-methoxyacrylate- based strobilurin analogues

Strobilurins have become one of the most important classes of agricultural fungicides. To discover new strobilurin derivatives with high activity against resistant pathogens, a series of novel β-methoxyacrylate analogues were designed and synthesized by integrating substituted pyrimidine with a strobilurin pharmacophore. The compounds were confirmed and characterized by infrared, 1H nuclear magnetic resonance, elemental analysis and mass spectroscopy. The bioassays indicated that most of the compounds 1 exhibited potent antifungal activity against Colletotrichum orbiculare, Botrytis cinerea Pers and Phytophthora capsici Leonian at the concentration of 50 μg/mL. Exhilaratingly, compound 1a (R=methyl) showed better antifungal activity against all the tested fungi than the commercial strobilurin fungicide azoxystrobin. Copyright

Pyrimidine A2b selective antagonist compounds, their synthesis and use

The subject invention provides compounds having the structure: wherein R1 is substituted or unsubstituted phenyl or a 5-6 membered heterocyclic or heteroaromatic ring containing from 1 to 5 heteroatoms; R2 is hydrogen, or a substitut

Phenylpyrimidines as antidotes for protecting cultivated plants against phytotoxic damage caused by herbicides

Phenylpyrimidines of the formula I as defined below are suitable as antidotes for protecting cultivated plants from phytotoxic effects caused by herbicides. These antidotes, either together with the herbicides or also by themselves, are applied to the pla

4-Amino-2-phenyl-6-thiopryimidines

The invention is directed to 4-amino-2-phenyl-6-thiopyrimidine compounds having the formula SPC1 Where R1 -R3 are as defined in the specification. The compounds have pharmacodynamic activity as central nervous system depressants. That is, they produce a calming effect in the host.