14401-51-5

Basic information

• Product Name: 4-Chlorobenzene-1-carboximidamide hydrochloride
• Synonyms: 4-Chlorobenzamidine hydrochloride ,95%;4-Chlorobenzenecarboximidamide hydrochloride, 4-Chlorobenzimidamide hydrochloride;4-chlorobenzimidamide hydrochloride;Benzenecarboximidamide,4-chloro-, hydrochloride (1:1);4-chlorobenzenecarboximidamidemonohydrochloride;4-chloro-benzenecarboximidamidmonohydrochloride;p-chloro-benzamidhydrochloride;p-chloro-benzamidinmonohydrochloride
• CAS NO: 14401-51-5
• Molecular Formula: C₇H₇ClN₂*ClH
• Molecular Weight: 191.06
• EINECS: 1533716-785-6
• Product Categories: pharmacetical
• Mol File: 14401-51-5.mol
• Article Data: 12

Chemical Properties

• Melting Point: 244 °C
• Boiling Point: 241.1°Cat760mmHg
• Flash Point: 99.6°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.0366mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-Chlorobenzene-1-carboximidamide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chlorobenzene-1-carboximidamide hydrochloride(14401-51-5)
• EPA Substance Registry System: 4-Chlorobenzene-1-carboximidamide hydrochloride(14401-51-5)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-43-36-25
• Safety Statements: 26-36-37/39-45-36/37
• RTECS: CV6136200
• Hazardous Substances Data: 14401-51-5(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

4-Chlorobenzene-1-carboximidamide, HCl

InChI:InChI=1/C7H7ClN2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,(H3,9,10)

Upstream product

• 5033-28-3 4-chlorobenzamidoxime 
• 40546-41-6 ethyl-4-chlorobenzimidate hydrochloride 
• 623-03-0 4-Cyanochlorobenzene 

Downstream Products

• 623-03-0 4-Cyanochlorobenzene 
• 30886-09-0 4,6-bis-(4-chloro-phenyl)-1H-[1,3,5]triazin-2-one 
• 59541-08-1 2-(4-chloro-phenyl)-1H-pyrimidine-4,6-dione 
• 66744-01-2 4-chloro-2-(4-chlorophenyl)-6-methylpyrimidine 
• 26870-72-4 4,6-dichloro-2-(4-chlorophenyl)-pyrimidine 
• 856972-94-6 6-chloro-2-(4-chloro-phenyl)-pyrimidin-4-ylamine 
• 859208-43-8 4-chloro-2-(4-chloro-phenyl)-6-methoxy-pyrimidine 
• 87753-10-4 2-(4-chlorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-ol 
• 1268853-91-3 2-(4-chlorophenyl)-5-(hydroxymethyl)-4-phenyl-4,5,6,7-tetrahydro-3H-imidazo[4,5-b]pyridine-6,7-diol 
• 1268853-92-4 4-benzyl-2-(4-chlorophenyl)-5-(hydroxymethyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-b]pyridine-6,7-diol 
• 56413-64-0 3,5-bis(4-chlorophenyl)-1H-1,2,4-triazole 

Relevant articles and documents

Preparation of amidines from amidoximes via transfer hydrogenation

Amidoximes are reduced into amidine using triethyl silane and PdCl 2 in acetic acid. Copyright

Investigation of new 2-aryl substituted Benzothiopyrano[4,3-d[pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2

Vascular Endothelial Growth Factor (VEGF) pathway has emerged as one of the most important positive modulators of Angiogenesis, a central process implicated in tumour growth and metastatic dissemination. This led to the design and development of anti-VEGF monoclonal antibodies and small-molecule ATP-competitive VEGFR-inhibitors. In this study, we describe the synthesis and the biological evaluation of novel 2-aryl substituted benzothiopyrano-fused pyrimidines 1a-i, 2a-i and 3a-i. The ability of the compounds to target the VEGF pathway was determined in vitro exploiting the compounds' antiproliferative efficacy against HUVEC cells. The VEGFR-2 inhibition was confirmed by enzymatic assays on recombinant human kinase insert domain receptor (KDR), by cell-based phospho-VEGFR-2 inhibition assays, and by ex vivo rat aortic ring tests. The selectivity profile of the best performing derivatives belonging to series 2 was further explored combining modeling studies and additional assays in a panel of human cell lines and other kinases.

Discovery and biological evaluation of novel 4-amino-2-phenylpyrimidine derivatives as potent and orally active GPR119 agonists

Novel 4-amino-2-phenylpyrimidine derivatives were synthesized and evaluated as GPR119 agonists. Optimization of the substituents on the phenyl ring at the 2-position and the amino group at the 4-position led to the identification of 3,4-dihalogenated and