268734-34-5

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 4-cyano-3-fluorobenzoate is used as a starting material for the synthesis of various pharmaceuticals. Its unique structure and functional groups make it a valuable component in the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, Methyl 4-cyano-3-fluorobenzoate is employed as a precursor for the production of various agrochemicals. Its chemical properties allow for the creation of compounds that can be used in pest control, crop protection, and other agricultural applications.
Used in Organic Synthesis:
Methyl 4-cyano-3-fluorobenzoate is utilized as a versatile building block in organic synthesis. Its reactivity and functional groups enable the formation of a wide range of organic compounds, contributing to the advancement of chemical research and the development of new materials and products.

InChI:InChI=1/C9H6FNO2/c1-13-9(12)6-2-3-7(5-11)8(10)4-6/h2-4H,1H3

Upstream product

• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 105942-08-3 4-bromo-6-fluorobenzonitrile 
• 77-78-1 dimethyl sulfate 
• 176508-81-9 4-cyano-3-fluorobenzoic acid 

Downstream Products

• 176508-81-9 4-cyano-3-fluorobenzoic acid 
• 501904-27-4 methyl 3-aminobenzo[d]isoxazole-6-carboxylate 
• 1044945-84-7 methyl 4-[amino(hydroxyimino)methyl]-3-fluorobenzoate 
• 737802-21-0 4-cyano-3-isopropylideneaminooxy-benzoic acid methyl ester 
• 1267508-15-5 methyl 4-cyano-3-(1H-pyrazol-1-yl)benzoate 
• 1267508-16-6 4-cyano-3-(1H-pyrazol-1-yl)benzoic acid 
• 1267507-40-3 4-cyano-N-[2-ethyl-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-6-methylphenyl]-3-(1H-pyrazol-1-yl)benzamide 
• 1267508-19-9 C₁₁H₆ClN₃O 
• 744200-36-0 methyl 4-((tert-butoxycarbonylamino)methyl)-3-fluorobenzoate 
• 101048-76-4 4-cyano-3-fluorobenzaldehyde 
• 1008520-27-1 2-[(Tetrahydro-furan-2-ylmethyl)-amino]-4-(1,5,5-trimethyl-7-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)-benzamide 
• 1008520-26-0 2-[(Tetrahydro-furan-2-ylmethyl)-amino]-4-(1,5,5-trimethyl-7-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)-benzonitrile 
• 1008520-25-9 2-Fluoro-4-(1,5,5-trimethyl-7-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)-benzonitrile 
• 222978-03-2 4-cyano-3-fluorobenzylbromide 

Relevant academic research and scientific papers

Optimization of Substrate-Analogue Furin Inhibitors

The proprotein convertase furin is a potential target for drug design, especially for the inhibition of furin-dependent virus replication. All effective synthetic furin inhibitors identified thus far are multibasic compounds; the highest potency was found for our previously developed inhibitor 4-(guanidinomethyl)phenylacetyl-Arg-Tle-Arg-4-amidinobenzylamide (MI-1148). An initial study in mice revealed a narrow therapeutic range for this tetrabasic compound, while significantly reduced toxicity was observed for some tribasic analogues. This suggests that the toxicity depends at least to some extent on the overall multibasic character of this inhibitor. Therefore, in a first approach, the C-terminal benzamidine of MI-1148 was replaced by less basic P1 residues. Despite decreased potency, a few compounds still inhibit furin in the low nanomolar range, but display negligible efficacy in cells. In a second approach, the P2 arginine was replaced by lysine; compared to MI-1148, this furin inhibitor has slightly decreased potency, but exhibits similar antiviral activity against West Nile and Dengue virus in cell culture and decreased toxicity in mice. These results provide a promising starting point for the development of efficacious and well-tolerated furin inhibitors.

NOVEL SULPHOXIMIDE-SUBSTITUTED QUINOLINE AND QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS

Novel sulphoximide-substituted quinoline and quinazoline derivatives as kinase inhibitors The present invention relates to quinoline and quinazoline derivatives of the general formula (I) in which W, Y, R3 and R4 are indicated in the

Palladium-catalyzed carbonylation reactions of aryl bromides at atmospheric pressure: A general system based on xantphos

(Chemical Equation Presented) A method for the Pd-catalyzed carbonylation of aryl bromides has been developed using Xantphos as the ligand. This method is effective for the direct synthesis of Weinreb amides, 1° and 2° benzamides, and methyl esters from the corresponding aryl bromides at atmospheric pressure. In addition, a putative catalytic intermediate, (Xanphos)Pd(Br)benzoyl, was prepared and an X-ray crystal structure was obtained revealing an unusual cis-coordination mode of Xantphos in this palladium-acyl complex.

Benzene, Pyridine, and Pyridazine Derivatives

Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q1, Q2, Q3, R31, and R41 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and

INDOLE-DERIVATIVE MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, comprising administering to a patient in thereof an effective amount of a compound of Formula I.

Farnesyltransferase inhibitors

Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

Farnesyltransferase inhibitors

Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.