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2-phenoxybenzene-1-sulfonyl chloride, also known as 2-phenoxybenzenesulfonyl chloride or phenoxybenzenesulfonyl chloride, is an organic compound with the chemical formula C12H9ClO3S. It is a colorless to pale yellow crystalline solid that is soluble in organic solvents. 2-phenoxybenzene-1-sulfonyl chloride is primarily used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals. It is also employed as a reagent in the preparation of sulfonamide derivatives and other sulfur-containing compounds. Due to its reactivity, it is essential to handle 2-phenoxybenzene-1-sulfonyl chloride with care, as it can cause irritation to the eyes, skin, and respiratory system.

2688-85-9

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2688-85-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2688-85-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,6,8 and 8 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 2688-85:
(6*2)+(5*6)+(4*8)+(3*8)+(2*8)+(1*5)=119
119 % 10 = 9
So 2688-85-9 is a valid CAS Registry Number.

2688-85-9Relevant academic research and scientific papers

Probing the isoprenylcysteine carboxyl methyltransferase (Icmt) binding pocket: Sulfonamide modified farnesyl cysteine (SMFC) analogs as Icmt inhibitors

Majmudar, Jaimeen D.,Hahne, Kalub,Hrycyna, Christine A.,Gibbs, Richard A.

supporting information; experimental part, p. 2616 - 2620 (2011/06/20)

Human isoprenylcysteine carboxyl methyltransferase (hIcmt) is a promising anticancer target as it is important for the post-translational modification of oncogenic Ras proteins. We herein report the synthesis and biochemical activity of 41 farnesyl-cystei

Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide

Shahripour, Aurash B,Plummer, Mark S,Lunney, Elizabeth A,Sawyer, Tomi K,Stankovic, Charles J,Connolly, Michael K,Rubin, John R,Walker, Nigel P.C,Brady, Kenneth D,Allen, Hamish J,Talanian, Robert V,Wong, Winnie W,Humblet, Christine

, p. 2779 - 2782 (2007/10/03)

A series of compounds was designed and prepared as inhibitors of interleukin-1β converting enzyme (ICE), also known as caspase-1. These inhibitors, which employ a diphenyl ether sulfonamide, were designed to improve potency by forming favorable interactions between the diphenyl ether rings and the prime side hydrophobic region. An X-ray crystal structure of a representative member of the diphenyl ether sulfonamide series bound to the active site of caspase-1 was obtained.

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