389623-92-1

Basic information

• Product Name: N-methoxy-N-methyl-3-(2-phenoxy-benzenesulfonylamino)-succinamic acid tert-butyl ester
• CAS NO: 389623-92-1
• Molecular Weight: 464.54
• Mol File: 389623-92-1.mol

Chemical Properties

• CAS DataBase Reference: N-methoxy-N-methyl-3-(2-phenoxy-benzenesulfonylamino)-succinamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-methoxy-N-methyl-3-(2-phenoxy-benzenesulfonylamino)-succinamic acid tert-butyl ester(389623-92-1)
• EPA Substance Registry System: N-methoxy-N-methyl-3-(2-phenoxy-benzenesulfonylamino)-succinamic acid tert-butyl ester(389623-92-1)

Safety Data

• Hazardous Substances Data: 389623-92-1(Hazardous Substances Data)

Upstream product

• 2688-85-9 phenoxybenzenesulfonyl chloride 
• 109364-30-9 (S)-3-amino-N-methoxy-N-methyl-succinamic acid tert-butyl ester 
• 2216-12-8 1-nitro-2-phenoxy-benzene 
• 108-95-2 phenol 
• 2688-84-8 2-phenoxyaniline 
• 1493-27-2 ortho-nitrofluorobenzene 

Downstream Products

• 389623-94-3 4-oxo-3-(2-phenoxy-benzenesulfonylamino)-butyric acid tert-butyl ester 

Relevant articles and documents

Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide

A series of compounds was designed and prepared as inhibitors of interleukin-1β converting enzyme (ICE), also known as caspase-1. These inhibitors, which employ a diphenyl ether sulfonamide, were designed to improve potency by forming favorable interactions between the diphenyl ether rings and the prime side hydrophobic region. An X-ray crystal structure of a representative member of the diphenyl ether sulfonamide series bound to the active site of caspase-1 was obtained.