2688-90-6

Basic information

• Product Name: 2-PHENYLBENZENESULPHONYL CHLORIDE
• Synonyms: 2-PHENYLBENZENESULPHONYL CHLORIDE;Biphenyl-2-sulphonyl chloride;2-Phenylphenylsulfonyl chloride;Biphenyl-2-sulfonic acid chloride
• CAS NO: 2688-90-6
• Molecular Formula: C₁₂H₉ClO₂S
• Molecular Weight: 252.71666
• Mol File: 2688-90-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 391.6 °C at 760 mmHg
• Flash Point: 190.7 °C
• Appearance: /
• Density: 1.32 g/cm³
• Vapor Pressure: 5.48E-06mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: 2-PHENYLBENZENESULPHONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYLBENZENESULPHONYL CHLORIDE(2688-90-6)
• EPA Substance Registry System: 2-PHENYLBENZENESULPHONYL CHLORIDE(2688-90-6)

Safety Data

• Hazardous Substances Data: 2688-90-6(Hazardous Substances Data)

Usage

General Description

2-Phenylbenzenesulphonyl chloride is a chemical compound with the formula C12H9ClO2S. It is a white crystalline solid that is used as an intermediate in the production of various pharmaceuticals and agrochemicals. 2-Phenylbenzenesulphonyl chloride is a highly reactive compound that is used as a reagent in organic synthesis to introduce the sulfonyl chloride functional group into organic molecules. 2-PHENYLBENZENESULPHONYL CHLORIDE is also used in the production of dyes, pigments, and other specialty chemicals. It is important to handle 2-phenylbenzenesulphonyl chloride with caution, as it is corrosive and can cause severe skin and eye irritation.

InChI:InChI=1/C12H9ClO2S/c13-16(14,15)12-9-5-4-8-11(12)10-6-2-1-3-7-10/h1-9H

Upstream product

• 109-72-8 n-butyllithium 
• 2052-07-5 2-Bromobiphenyl 
• 2688-84-8 2-phenoxyaniline 
• 90-41-5 2-phenylaniline 
• 2113-51-1 2-iodobiphenyl 

Downstream Products

• 1016-05-3 dibenzothiophene sulfone 
• 1429765-85-4 methyl 2-((4-([1,1′-biphenyl]-2-ylsulfonamido)-1-methoxynaphthalen-2-yl)thio)acetate 
• 1446481-61-3 C₃₃H₃₄FN₃O₃S 
• 1007873-76-8 (2RS)-[1-(biphenyl-2-sulfonyl)azetidin-2-ylmethyl]carbamic acid tert-butyl ester 
• 1021170-64-8 C₂₆H₂₉ClN₂O₃S 
• 1019217-34-5 methyl 4-[3-(1-benzhydryl-2-{2-[(1,1'-biphenyl-2-ylsulfonyl)amino]ethyl}-5-chloro-1H-indol-3-yl)propyl]benzoate 
• 1019216-92-2 methyl 4-[2-(1-benzhydryl-2-{2-[(1,1'-biphenyl-2-ylsulfonyl)amino]ethyl}-5-chloro-1H-indol-3-yl)ethoxy]benzoate 
• 62533-09-9 C₃₀H₂₄NO₂PS 
• 19813-97-9 1-phenyl-2-[(2-phenylphenyl)disulfanyl]benzene 
• 40182-08-9 N-Phenylbiphenyl-2-sulfonamid 
• 62533-20-4 N-Cyclohexylbiphenyl-2-sulfonamid 
• 40182-06-7 (1,1'-biphenyl)-2-sulphonamide 

Relevant articles and documents

Inhibitors of cytosolic phospholipase A2

This invention provides substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.

N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin

Thienyl-, furyl- and pyrrolyl-sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl)furylsulfonamides and N-(isoxazolyl)pyrrolylsulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.

PHENYL SULFONAMIDE ENDOTHELIN ANTAGONISTS

Compounds of the formula STR1 inhibit the activity of endothelin. The symbols are defined as follows: R 1, R 2 and R. sup.3 are each independently(a) hydrogen, except that R. sup.1 is other than hydrogen;(b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z 1, Z 2 and Z. sup.3 ;(c) halo;(d) hydroxyl;(e) cyano; (f) nitro; (g)--C(O)H or--C(O)R 6 ;(h)--CO 2 H or--CO 2 R 6 ; (i)--SH,--S(O) n R 6,--S(O) m--OH,--S(O) m--OR 6,--O--S(O) m--R 6,--O--S(O) m OH or--O--S(O) m--OR. sup.6 ;(j)--Z. sup.4--NR 7 R 8 ; or (k)--Z 4--N(R 11--Z 5--NR 9 R 10 ; and the remaining symbols are as defined in the specification.