40182-06-7

Upstream product

• 179250-70-5 2'-Amino-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide 
• 153624-04-5 N-(3,4-Dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)-[1,1'-biphenyl]-2-sulfonamide 
• 318-13-8 [1,1'-biphenyl]-2-diazonium tetrafluoroborate 
• 591-50-4 iodobenzene 
• 105441-80-3 methyl 2-methyl-2-(phenylsulfonylamido)propionic acid 
• 153623-88-2 3'-Amino-N-(3,4-dimethyl-5-isoxazolyl)[1,1'-biphenyl]-2-sulfonamide 
• 2688-90-6 2-phenylbenzenesulfonyl chloride 

Downstream Products

• 221289-06-1 4'-(2-Cyclohexylethyl)biphenyl-2-sulfonylcyanamide 

Relevant academic research and scientific papers

Sulfonamide compound and synthesis method and application thereof

The invention discloses a synthesis method of a sulfonamide compound represented in a formula (2). According to the method, diazonium salt is used as a reaction raw material, and under the action of an inorganic nitrogen reagent, an inorganic sulfur dioxide reagent, an additive and a phosphine reagent, the diazonium salt is reacted in a solvent at 60-100 DEG C to obtain various sulfonamide compounds. According to the method inorganic salt is used as a nitrogen atom source and a sulfur dioxide source under a metal-free catalytic condition to construct the sulfonamide compound through one step,thereby avoiding the conventional multi-step synthesis of sulfonamide by condensing unstable acid chloride and amine; and the developed sulfonamide synthesis method can be further applied to the synthesis of the arthritis drug celecoxib and the psychotropic drug sulpiride.

Metal-free construction of primary sulfonamides through three diverse salts

In this report, the first metal-free construction of primary sulfonamides through a direct three-component reaction of sodium metabisulfite, sodium azide and aryldiazonium has been established. Readily available inorganic Na2S2O5 and NaN3 were applied as the sulfur dioxide surrogate and nitrogen source respectively. The widely used sulfonamide drugs Celecoxib and Sulpiride, which possess multiple heteroatoms and active hydrogen containing functional groups, are efficiently installed with -SO2NH2 groups at a late stage. Control experiments and kinetic studies demonstrated that aryl radicals, sulfonyl radicals and conjugated phosphine imine radicals are involved in this transformation.

Palladium(II)/copper(I)-catalyzed sequential C[sbnd]H arylation and oxidative C[sbnd]N bond cleavage of aryl sulfonamino acids: Efficient one-pot synthesis of primary biaryl sulfonamides

A versatile strategy for the one-pot synthesis of primary biaryl-based sulfonamides has been developed via a tandem process consisting of palladium-catalyzed C[sbnd]H arylation and subsequent copper-catalyzed oxidative C[sbnd]N bond cleavage of aryl sulfonamino acids. Both electron-withdrawing and electron-donating functionalities can be introduced into the ortho positions of arenes bearing a variety of substituents. The amio acid moiety not only acts as a directing group but also as an ammonia synthetic equivalent. Importantly, the directing group was smoothly removed in the presence of catalytic CuI by using air as a sole oxidant.

PHENYL SULFONAMIDE ENDOTHELIN ANTAGONISTS

Compounds of the formula STR1 inhibit the activity of endothelin. The symbols are defined as follows: R 1, R 2 and R. sup.3 are each independently(a) hydrogen, except that R. sup.1 is other than hydrogen;(b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z 1, Z 2 and Z. sup.3 ;(c) halo;(d) hydroxyl;(e) cyano; (f) nitro; (g)--C(O)H or--C(O)R 6 ;(h)--CO 2 H or--CO 2 R 6 ; (i)--SH,--S(O) n R 6,--S(O) m--OH,--S(O) m--OR 6,--O--S(O) m--R 6,--O--S(O) m OH or--O--S(O) m--OR. sup.6 ;(j)--Z. sup.4--NR 7 R 8 ; or (k)--Z 4--N(R 11--Z 5--NR 9 R 10 ; and the remaining symbols are as defined in the specification.