269085-45-2Relevant academic research and scientific papers
Design and efficient synthesis of amino acid derived 2-substituted imidazoles by palladium-catalyzed cross-coupling reactions
Marek, Ales,Kulhanek, Jiri,Bures, Filip
body text, p. 325 - 331 (2009/06/27)
Optically active imidazole derivatives featuring an α-amino acid motif substituted at the 2-position can be prepared in moderate to good yields by Negishi as well as Suzuki-Miyaura cross-couplings as the key synthetic steps. The reaction sequence involves
Facile synthesis of optically active imidazole derivatives
Marek, Ales,Kulhanek, Jiri,Ludwig, Miroslav,Bures, Filip
, p. 1183 - 1190 (2008/02/07)
Five optically active imidazole derivatives have been synthesized via a facile 4-step reaction sequence starting from commercially available and inexpensive N-Cbz amino acids. While microwave assisted condensation was unsuccessful, the condensation of the
Synthesis of amino acid-derived imidazoles from enantiopure N-protected α-amino glyoxals
Groarke, Michelle,McKervey, M. Anthony,Nieuwenhuyzen, Mark
, p. 1275 - 1278 (2007/10/03)
A range of novel imidazoles, including three histidine derivatives, with chiral side chains derived from amino acids and dipeptides have been synthesised from N-Cbz-protected α-amino glyoxals. (C) 2000 Elsevier Science Ltd.
