26928-12-1

Basic information

• Product Name: 2-Propenoic acid, 2-fluoro-3-(4-methoxyphenyl)-, (Z)-
• Synonyms: 2-Propenoic acid,2-fluoro-3-(4-methoxyphenyl)-,(Z);2-fluoro-3-(4-methoxy-phenyl)-propenoic acid;(Z)-2-fluoro-3-(4-methoxyphenyl)-2-propenoic acid
• CAS NO: 26928-12-1
• Molecular Formula: C10H9FO3
• Molecular Weight: 196.178
• Mol File: 26928-12-1.mol

Chemical Properties

• Boiling Point: 348.1±27.0 °C(Predicted)
• Density: 1.271±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-Propenoic acid, 2-fluoro-3-(4-methoxyphenyl)-, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-fluoro-3-(4-methoxyphenyl)-, (Z)-(26928-12-1)
• EPA Substance Registry System: 2-Propenoic acid, 2-fluoro-3-(4-methoxyphenyl)-, (Z)-(26928-12-1)

Safety Data

• Hazardous Substances Data: 26928-12-1(Hazardous Substances Data)

Upstream product

• 26927-88-8 (Z)-3-(4-methoxyphenyl)-2-fluoroacrylic acid ethyl ester 
• 2356-16-3 ethyl(diethylphosphono)(fluoro)acetate 
• 123-11-5 4-methoxy-benzaldehyde 
• 1198794-78-3 C₁₀H₉ClF₄O₂ 
• 30094-32-7 (diethoxy phosphoryl) fluoroacetic acid 
• 26928-11-0 (E)-2-fluoro-3-(4-methoxyphenyl)acrylic acid 

Downstream Products

• 130490-04-9 (2R,3R)-2,3-Dibromo-2-fluoro-3-(4-methoxy-phenyl)-propionic acid 
• 130490-04-9 (2R,3S)-2,3-Dibromo-2-fluoro-3-(4-methoxy-phenyl)-propionic acid 
• 130490-08-3 (Z)-1-bromo-1-fluoro-3-(4-methoxyphenyl)ethylene 
• 130490-09-4 (E)-1-(2-bromo-2-fluorovinyl)-4-methoxybenzene 
• 26928-26-7 (Z)-1-Fluoro-2-(4-methoxyphenyl)ethylene 

Relevant articles and documents

OPTICALLY ACTIVE PYRROLIDINE COMPOUND AND METHOD FOR PRODUCING SAME

The present invention provides: a methyl 1-{2-[(3S,4R)-1-[(3R,4R)-1-cyclopentyl-3-fluoro-4-(4-methoxyphenyl) pyrrolidine-3-carbonyl]-4-(methoxymethyl)pyrrolidin-3-yl]-5-(trifluoromethyl) phenyl}piperidine-4-carboxylate 1/2 ethane-1,2-disulfonic acid which is represented by formula (1) and is excellent in crystallinity; and a method for producing the same; and a production intermediate thereof; and a production method using this compound.

Pd-and Cu-catalyzed stereo-and regiocontrolled decarboxylative/C-H fluoroalkenylation of heteroarenes

Pd/Cu-catalyzed decarboxylative/direct C-H alkenylations of heteroarenes with α-fluoroacrylic acid is reported. This method offers step-economical and stereocontrolled access to valuable heteroarylated monofluoroalkenes as both Z and E isomers, which are known to be useful in the synthesis of fluorinated biomolecules.

An efficient synthesis of (Z)-α-fluorochalcones via the palladium-catalyzed cross-coupling reaction of (Z)-α-fluorocinnamoyl chloride with boronic acids

An efficient synthesis of α-fluorochalcones (1,3-diphenyl-2- fluoroprop-2-en-1-one) based on the Suzuki-Miyaura palladium-catalyzed cross-coupling reaction of arylboronic acids with α-fluorocinnamoyl chlorides in the presence of Cs2CO3/su

Synthetic utilization of 2-chloro-1,1,1,2-tetrafluoroethane

β-Substituted α-fluoro-α,β-unsaturated carboxylic acids have been successfully synthesized, usually in a (Z)-stereospecific manner by way of a stepwise or a one-pot three-step procedure starting from 2-chloro-1,1,1,2-tetrafluoroethane (HCFC-124), one of the major byproducts of the industrial process for tetrafluoroethene formation from chlorofluoromethane (HCFC-22). Get some Z's! β-Substituted α-fluoro-α,β- unsaturated carboxylic acids have been successfully synthesized from 2-chloro-1,1,1,2-tetrafluoroethane, one of the major byproducts of tetrafluoroethene formation from chlorofluoromethane. The products are usually obtained with Z stereoselectivity, by either a stepwise or a one-pot three-step procedure (see scheme).

A novel reaction of β,β'-dihydroxy acids or esters with vanadium(V) trichloride oxide. New entry to the stereoselective synthesis of α-fluoro- α,β-unsaturated acids and esters

β,β'-Dihydroxy carboxylic acids and esters, readily prepared from dibromofluoroacetate and aldehydes, underwent deoxygenation, followed by elimination of aldehyde by the action of vanadium(V) trichloride oxide at the reflux temperature of chlorobenzene fo

Synthesis of fluorinated enynes via 1-bromo 1-fluoro alkenes

A stereospecific synthesis of fluorinated enynes was performed through palladium catalysed condensation of 1-bromo 1-fluoro 2-arylethylenes, synthetised from 1-carboxyl 1-fluoro 2-arylethylene with monosubstitued alkynes.

2-Diethoxyphosphoryl alcanoic acid dianions (lithium α-lithiocarboxylates) IV. A direct route to 2-fluoro-2-alkenoic acids by the Horner synthesis. Application in the field of pyrethroids

2-Diethoxyphosphoryl-2-fluoroacetic acid was converted into the lithium α lithiocarboxylate dianion by treatment with n-butyllithium in hexane/tetrahydrofuran at -70 deg C.The Horner reaction between this new dianion and carbonyl compounds gave various 2-fluoro-2alkenoic acids.Application of the method to the cis,trans caronaldehyde ethyl esters led to the 2-fluoroethenyl pyrethroid derivatives (Z-cis, E-cis, Z-trans, E-trans).