26944-42-3

Usage

Physical state

Colorless, clear liquid

Odor

Strong

Uses

a. Solvent
b. Intermediate in the production of various chemicals and pharmaceuticals

Boiling point

High

Water solubility

Low

Applications

a. Reaction chemistry
b. Organic synthesis

Stability

a. High thermal stability
b. High chemical stability

Suitability

a. High-temperature processes
b. Harsh chemical environments

Potential use

Building block for the synthesis of complex organic molecules

Upstream product

• 4292-19-7 1-Iodododecane 
• 1546-79-8 N-trifluoroacetylimidazole 
• 383-63-1 ethyl trifluoroacetate, 
• 143-15-7 1-dodecylbromide 
• 76-05-1 trifluoroacetic acid 
• 78904-63-9 (dodecylsulfonyl)benzene 
• 15890-72-9 laurylmagnesium bromide 
• 853569-40-1 3-benzenesulfonyl-1,1,1-trifluoro-tetradecan-2-one 

Downstream Products

• 193202-44-7 Trifluoromethyl dodecyl ketone benzyl oxime 

Relevant academic research and scientific papers

An efficient and expeditious synthesis of funcionalized trifluoromethyl ketones through lithium-iodine exchange reaction

A straightforward and very efficient synthesis of unsaturated long-chain trifluoromethyl ketones is achieved by metallation of the corresponding iodides in the presence of an equimolecular amount of tert-butyllithium, followed by reaction with a fluoroacylating agent.Metallation occurs quantitatively at -78 deg C and, in contrast to what has been generally recommended, there is no need to add the second equivalent of base, since its presence may be detrimental if other electrophilic functions are present in the molecule.

Locking out ants - Synthesis and biological evaluation of some fluorinated repellents

We synthesized a series of fluorinated compounds and tested them in an easy assay for their repellent activity against the ant Myrmica rubra. Depending on their chain length and pattern of fluorination these molecules are efficient repellents for this ant. Fluorinated compounds are stronger repellents than their unfluorinated analogs. 1,1,1-Trifluorotridecan-2-one (4) is an even better repellent against M. rubra than "gold standard" N,N-diethyl-m- toluamide (DEET).

A new, practical and efficient sulfone-mediated synthesis of trifluoromethyl ketones from alkyl and alkenyl bromides

We report herein a new and efficient method to prepare trifluoromethyl ketones from the corresponding bromides through sulfones in good yields.

A convenient preparative method for α-trifluoromethyl amines

α-Trifluoromethyl amines (IV) were prepared in three steps: preparation of α-trifluoromethyl ketones (I), their conversion to benzyloximes (II), and reduction of the oximes (II) with lithium aluminium hydride and sodium methoxide. For example, α-trifluoromethyltridecylamine was obtained from the reduction of trifluoromethyl dodecyl ketone benzyl oxime. Elsevier Science S.A.