26944-42-3Relevant articles and documents
An efficient and expeditious synthesis of funcionalized trifluoromethyl ketones through lithium-iodine exchange reaction
Villuendas, Isabel,Parrilla, Alfredo,Guerrero, Angel
, p. 12673 - 12684 (1994)
A straightforward and very efficient synthesis of unsaturated long-chain trifluoromethyl ketones is achieved by metallation of the corresponding iodides in the presence of an equimolecular amount of tert-butyllithium, followed by reaction with a fluoroacylating agent.Metallation occurs quantitatively at -78 deg C and, in contrast to what has been generally recommended, there is no need to add the second equivalent of base, since its presence may be detrimental if other electrophilic functions are present in the molecule.
A new, practical and efficient sulfone-mediated synthesis of trifluoromethyl ketones from alkyl and alkenyl bromides
Mu?oz, Lourdes,Rosa, Esmeralda,Bosch, Ma. Pilar,Guerrero, Angel
, p. 3311 - 3313 (2007/10/03)
We report herein a new and efficient method to prepare trifluoromethyl ketones from the corresponding bromides through sulfones in good yields.
