26944-43-4

Basic information

• Product Name: Ethanone, 2,2,2-trifluoro-1-(2-methoxyphenyl)- (9CI)
• Synonyms: Ethanone, 2,2,2-trifluoro-1-(2-methoxyphenyl)- (9CI);2,2,2-trifluoro-1-(2-Methoxyphenyl)ethanone;2,2,2-trifluoro-1-(2-methoxyphenyl)ethan-1-one
• CAS NO: 26944-43-4
• Molecular Formula: C₉H₇F₃O₂
• Molecular Weight: 204.1458896
• Product Categories: ACETYLHALIDE
• Mol File: 26944-43-4.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 212.3°Cat760mmHg
• Flash Point: 80.1°C
• Appearance: /
• Density: 1.265g/cm³
• Vapor Pressure: 0.175mmHg at 25°C
• Refractive Index: 1.45
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Ethanone, 2,2,2-trifluoro-1-(2-methoxyphenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2,2,2-trifluoro-1-(2-methoxyphenyl)- (9CI)(26944-43-4)
• EPA Substance Registry System: Ethanone, 2,2,2-trifluoro-1-(2-methoxyphenyl)- (9CI)(26944-43-4)

Safety Data

• Hazardous Substances Data: 26944-43-4(Hazardous Substances Data)

Usage

General Description

Ethanone, 2,2,2-trifluoro-1-(2-methoxyphenyl)- (9CI) is a chemical compound that belongs to the class of ketones and contains a 2,2,2-trifluoro-1-(2-methoxyphenyl) group. Ethanone, 2,2,2-trifluoro-1-(2-methoxyphenyl)- (9CI) is most commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also utilized in various organic reactions and as a solvent in chemical processes. Due to its unique chemical structure and properties, Ethanone, 2,2,2-trifluoro-1-(2-methoxyphenyl)- (9CI) has a wide range of potential applications in the field of organic chemistry and industrial manufacturing. It is important to handle this compound with care and follow proper safety protocols when working with it.

InChI:InChI=1/C9H7F3O2/c1-14-7-5-3-2-4-6(7)8(13)9(10,11)12/h2-5H,1H3

Upstream product

• 500-73-2 phenyl trifluoroacetate 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 383-63-1 ethyl trifluoroacetate, 
• 578-57-4 2-bromoanisole 
• 340-07-8 N-(trifluoroacetyl)piperidine 
• 529-28-2 4-iodoanisol 
• 533-58-4 2-Iodophenol 
• 108-95-2 phenol 
• 135-02-4 ortho-anisaldehyde 
• 26902-84-1 2,2,2-trifluoro-1-(2-methoxyphenyl)ethanol 
• 431-47-0 trifluoroacetic acid-methyl ester 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 16750-63-3 2-methoxyphenylmagnesium bromide 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 1384244-43-2 (S)-5,5,5-trifluoro-4-hydroxy-4-(2-methoxyphenyl)pentan-2-one 
• 42452-41-5 2,2,2-trifluoro-1-(2-methoxyphenyl)ethanone oximeoxime 
• 1469268-20-9 2,2,2-trifluoro-1-(2-methoxyphenyl)ethan-1-one o-tosyl oxime 
• 1469268-21-0 3-(2-methoxyphenyl)-3-(trifluoromethyl)diaziridine 
• 1469268-22-1 3-(2-methoxyphenyl)-3-(trifluoromethyl)-3H-diazirine 
• 1469268-23-2 2-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenol 
• 1469268-24-3 ethyl 2-(2-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenoxy)acetate 
• 1469268-25-4 2-(2-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenoxy)acetic acid 
• 1469268-03-8 prop-2-ynyl 4-hydroxy-3-(2-(2-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenoxy)acetamido)benzoate 

Relevant articles and documents

Oxidation of fluoroalkyl alcohols using sodium hypochlorite pentahydrate [1]

Fluoroalkyl alcohols are effectivity oxidized to the corresponding fluoroalkyl carbonyl compounds by reaction with sodium hypochlorite pentahydrate in acetonitrile in the presence of acid and nitroxyl radical catalysts. Although the reaction proceeded slower under a nitroxyl radical catalyst- free condition, the desired carbonyl compounds were obtained in high yields. For the reaction with fluoroalkyl allylic alcohols, the corresponding α,β-epoxyketone hydrates were obtained in high yields.

Oxidation of α-trifluoromethyl and non-fluorinated alcohols: Via the merger of oxoammonium cations and photoredox catalysis

We present an alcohol oxidation strategy to access α-trifluoromethyl ketones (TFMKs) merging catalytic oxoammonium cation oxidation with visible-light photoredox catalysis. This work uses 4-acetamido-(2,2,6,6-tetramethyl-piperidin-1-yl)oxyl as an organic oxidant capable of generating TFMKs in good yields. The methodology serves as an improvement over previous reports of an analogous oxidation strategy requiring superstoichiometric quantities of oxidant. Both primary and secondary non-fluorinated alcohols can also be oxidised in good yields.

Synthesis and structure-activity relationship study of chemical probes as hypoxia induced factor-1α/malate dehydrogenase 2 inhibitors

A structure-activity relationship study of hypoxia inducible factor-1α inhibitor 3-aminobenzoic acid-based chemical probes, which were previously identified to bind to mitochondrial malate dehydrogenase 2, was performed to provide a better understanding of the pharmacological effects of LW6 and its relation to hypoxia inducible factor-1α (HIF-1α) and malate dehydrogenase 2 (MDH2). A variety of multifunctional probes including the benzophenone or the trifluoromethyl diazirine for photoaffinity labeling and click reaction were prepared and evaluated for their biological activity using a cell-based HRE-luciferase assay as well as a MDH2 assay in human colorectal cancer HCT116 cells. Among them, the diazirine probe 4a showed strong inhibitory activity against both HIF-1α and MDH2. Significantly, the inhibitory effect of the probes on HIF-1α activity was consistent with that of the MDH2 enzyme assay, which was further confirmed by the effect on in vitro binding activity to recombinant human MDH2, oxygen consumption, ATP production, and AMP activated protein kinase (AMPK) activation. Competitive binding modes of LW6 and probe 4a to MDH2 were also demonstrated.