2695-79-6

Basic information

• Product Name: 2,2-Bis(4-methylphenyl)glycolic acid
• Synonyms: 2,2-Bis(4-methylphenyl)glycolic acid;Bis(4-methylphenyl)hydroxyacetic acid;p-Tolilic acid;α-Hydroxy-4-methyl-α-(4-methylphenyl)benzeneacetic acid
• CAS NO: 2695-79-6
• Molecular Formula: C₁₆H₁₆O₃
• Molecular Weight: 256.2964
• Mol File: 2695-79-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 135 °C
• Boiling Point: 436.5°Cat760mmHg
• Flash Point: 232°C
• Appearance: /
• Density: 1.215g/cm³
• Vapor Pressure: 2.15E-08mmHg at 25°C
• Refractive Index: 1.603
• PKA: 3.57±0.10(Predicted)
• CAS DataBase Reference: 2,2-Bis(4-methylphenyl)glycolic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Bis(4-methylphenyl)glycolic acid(2695-79-6)
• EPA Substance Registry System: 2,2-Bis(4-methylphenyl)glycolic acid(2695-79-6)

Safety Data

• Hazardous Substances Data: 2695-79-6(Hazardous Substances Data)

Usage

General Description

2,2-Bis(4-methylphenyl)glycolic acid, also known as BMGA, is a chemical compound with the molecular formula C16H16O3. It is a white crystalline solid that is used in the production of organic pigments and dyes, as well as in the manufacture of pharmaceuticals and agrochemicals. BMGA is also used as a building block in the synthesis of various organic compounds. It is known for its high purity and stability, making it a valuable intermediate for the chemical industry. Additionally, BMGA has potential applications in the fields of materials science and biomedical research due to its unique structural and chemical properties.

InChI:InChI=1/C16H16O3/c1-11-3-7-13(8-4-11)16(19,15(17)18)14-9-5-12(2)6-10-14/h3-10,19H,1-2H3,(H,17,18)

Upstream product

• 3457-48-5 1,2-di(4-methylphenyl)-1,2-ethanedione 
• 1218-89-9 4,4'-dimethylbenzoin 
• 611-97-2 bis(p-methylphenyl)-methanone 
• 124-38-9 carbon dioxide 
• 111586-29-9 methyl 2-hydroxy-2,2-bis(4-methylphenyl)acetate 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 860539-65-7 tri-p-tolyl-acetic acid 
• 861074-08-0 (3-carboxy-4-hydroxy-[1]naphthyl)-di-p-tolyl-acetic acid 
• 111586-29-9 methyl 2-hydroxy-2,2-bis(4-methylphenyl)acetate 
• 762300-04-9 N-(3-{1-[3-({hydroxy[bis(4-methylphenyl)]acetyl}amino)propyl]-4-piperidinyl}-4-methylphenyl)-2-methylpropanamide 
• 762300-09-4 N-(2,4-difluoro-5-{1-[3-({hydroxy[bis(4-methylphenyl)]acetyl}amino)propyl]-4-piperidinyl}phenyl)-2-methylpropanamide 
• 861073-25-8 1-hydroxy-4-(α-hydroxy-4,4'-dimethyl-benzhydryl)-[2]naphthoic acid 
• 85258-76-0 5,5-Di-p-tolyl-thiazolidine-2,4-dione 

Relevant articles and documents

Microwave-assisted heterogeneous benzil-benzilic acid rearrangement

A new procedure for carrying out the benzil-benzilic acid rearrangement in the solid state has been developed which provides a new route to synthesize the pharmacologically interesting anticonvulsant dilantin.

QUINUCLIDINE DERIVATIVES AND THEIR USE AS MUSCARINIC M3 RECEPTOR ANTAGONISTS

Compounds of Formula (I) ; in salt or zwitterionic form wherein R 1, R2, R3 and R4 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor, especially inflammatory or obstructive airways diseases. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

Direct Observation of Ultrafast Decarboxylation of Acyloxy Radicals via Photoinduced Electron Transfer in Carboxylate Ion Pairs

Charge-transfer (CT) photoactivation of the electron donor-acceptor salts of methylviologen (MV2+) with carboxylate donors (RCO2-) including benzilates [Ar2C(OH)CO2-] and arylacetates (ArCH2CO2-) leads to transient [MV.+, RCO2.] radical pairs. Femtosecond time-resolved spectroscopy reveals that the photogenerated acyloxy radicals (RCO2.) rapidly lose carbon dioxide by C-CO2 bond cleavage, in competition with back-electron transfer to restore the original ion pair, [MV2+, RCO2-]. The decarboxylation rate constants for ArCH2CO2. lie in the range (1-2) × 109 s-1, in agreement with previous reports. In striking contrast, the C-CO2 bond scission in Ar2C(OH)CO2. occurs within a few picoseconds (kCC = (2-8) × 1011 s-1). The rate constants for decarboxylation of these donors approach those of barrier-free unimolecular reactions. Thus, real-time monitoring of the decarboxylation of benziloxy radicals represents the means for the direct observation of the transition state for C-C bond scission.