26972-04-3

Upstream product

• 4461-37-4 4-nitrobenzoylisocyanate 
• 67-56-1 methanol 
• 122-04-3 4-nitro-benzoyl chloride 
• 97246-50-9 methyl N-[methoxy(methylthio)methylene]carbamate 
• 79048-32-1 4-(tri-n-butylstannyl)nitrobenzene 

Downstream Products

• 1430217-73-4 (R)-methyl 4-(1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoylcarbamate 
• 1430217-72-3 methyl 4-aminobenzoylcarbamate 
• 1430216-57-1 (R,E)-methyl 4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoylcarbamate 

Relevant academic research and scientific papers

SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.

Preparation of imides via the palladium-catalyzed coupling reaction of organostannanes with methyl n-[methoxy(methylthio)methylene]carbamate

The preparation of imides via the palladium-catalyzed coupling reaction of organostannanes is described. The palladium-catalyzed coupling reaction of aryl-, heteroaryl-, and alkenyl(tributyl)stannanes with methyl N-[methoxy(methylthio)methylene]carbamate

Acidity of Benzoylcarbamates in Dimethyl Sulfoxide. Confirmation of Mixed N/O Alkylation in the Mitsunobu Reaction

Seventeen benzoyl-, 4-methoxybenzoyl-, and 4-nitrobenzoyl-carbamates have been synthesized via their corresponding isocyanates and their acidities determined in dimethyl sulfoxide solution.Their pKa values span an interval of nearly 5 pK units