269732-13-0

Upstream product

• 127590-90-3 3-(benzyloxy)-6-(chloromethyl)pyridine 
• 219638-16-1 2-acetylamino-2-(5-benzyloxy-pyridin-2-ylmethyl)-malonic acid diethyl ester 
• 219638-17-2 2-amino-3-(5-benzyloxy-pyridin-2-yl)-propionic acid 
• 219638-18-3 ((±)-3-(5-(benzyloxy)pyridine-2-yl)-2-(tert-butoxycarbonylamino)propanoic acid) 
• 100-39-0 benzyl bromide 

Relevant academic research and scientific papers

Selective cytotoxicity of azatyrosinamides against ras-transformed NIH 3T3 cells

This study aims to develop novel azatyrosinamide compounds structurally modified from ras-specific antioncogenic azatyrosine. Analogues 4-15 were prepared and their inhibition on the growth of wild-type and ras-transformed NIH 3T3 cell lines was compared. Compound 12 was found to be the most active with IC50 16.5 ± 2.2 μM which is 458-fold more potent than that of azatyrosine. The selective toxicity, defined as IC 50 wild-type/IC50 ras-transformed for this compound was 138.5.