26977-44-6Relevant articles and documents
1,4,2-Dioxazol-5-ones as Isocyanate Equivalents: Chemoselective Non-Metal-Catalyzed Carboxamidation of Indoles
Vala, Anand,Parmar, Deepa,Rayani, Rahul,Kusurkar, Rakesh,Guduru, Ramakrishna,Kaneriya, Uttam,Gondaliya, Uday,Parmar, Nirali,Soni, Jigar Y.
, (2022/02/21)
1,4,2-Dioxazol-5-ones are known to undergo decarboxylation under thermal conditions followed by Lossen s rearrangement to give isocyanates. Described herein is the in situ trapping of the isocyanates by indoles to give indole-3-carboxamides in good to exc
Chemoselective Cu-catalyzed synthesis of diverseN-arylindole carboxamides, β-oxo amides andN-arylindole-3-carbonitriles using diaryliodonium salts
Kumar Mehra, Manish,Malik, Monika,Kumar, Bintu,Kumar, Dalip
supporting information, p. 1109 - 1114 (2021/02/16)
Chemoselective copper-catalyzed synthesis of diverseN-arylindole-3-carboxamides, β-oxo amides andN-arylindole-3-carbonitriles from readily accessible indole-3-carbonitriles, α-cyano ketones and diaryliodonium salts has been developed. DiverseN-arylindole-3-carboxamides and β-oxo amides were successfully achieved in high yields under copper-catalyzed neutral reaction conditions, and the addition of an organic base (DIPEA) resulted in a completely different selectivity pattern to produceN-arylindole-3-carbonitriles. Moreover, the importance of the developed methodology was realized by the synthesis of indoloquinolones andN-((1H-indol-3-yl)methyl)aniline and by a single-step gram-scale synthesis of the naturally occurring cephalandole A analogue.
Synthesis of 4,6-disubstituted-2-(1H-indol-3-yl)-benzothiazoles
Zaletova, Janka,Dzurilla, Milan,Kutschy, Peter,Pazdera, Pavel,Kovacik, Vladimir,Aldoelfi, Juraj,Bekesova, Slavka
, p. 453 - 460 (2007/10/03)
A new four-step synthesis of substituted 2-(1H-indol-3-yl)benzothiazoles is described, using N3-phenyl-1H-indole-3-carbothioamides as key intermediates. The structure of the obtained products was determined by IR, 1H, 13C NMR and MS spectral methods.
