26987-36-0Relevant academic research and scientific papers
An aminophosphonate ester ligand-containing platinum(ii) complex induces potent immunogenic cell death: In vitro and elicits effective anti-tumour immune responses in vivo
Huang, Ke-Bin,Wang, Feng-Yang,Feng, Hai-Wen,Luo, Hejiang,Long, Yan,Zou, Taotao,Chan, Albert S. C.,Liu, Rong,Zou, Huahong,Chen, Zhen-Feng,Liu, Yan-Cheng,Liu, You-Nian,Liang, Hong
, p. 13066 - 13069 (2019)
A platinum(ii) complex containing an aminophosphonate ligand preferentially accumulates in the endoplamic reticulum (ER) in association with potent ER stress and reactive oxygen species generation, followed by the activation of damage-associated molecular pattern signals and immune responses. Importantly, the Pt complex exhibits potent anti-tumour activities in two independent mouse models via an immunogenic cell death pathway.
