26987-64-4Relevant articles and documents
-
Reich,Reichstein
, p. 1124,1131 (1939)
-
-
Reichstein,v. Euw
, p. 136,137, 138 (1940)
-
Affinity-Labelling Corticoids I. Synthesis of 21-Chloroprogesterone, Deoxycorticosterone 21-(1-Imidazole) Carboxylate, 21-Deoxy-21-Chloro Dexamethasone, and Dexamethasone 21-Mesylate, 21-Bromoacetate, and 21-Iodoacetate
Dunkerton, Lois V.,Markland, Francis S.,Li, Ming P.
, p. 1 - 6 (2007/10/02)
The efficient and unambiguous preparation of several C-21 substituted affinity-labelling corticoids are described.Included is an improved procedure for the preparation of 21-chloroprogesterone and the first reported synthesis of deoxycorticosterone 21-(1-imidazole) carboxylate.Dexamethasone derivatives prepared include seperate and unambiguous synthesis of 21-deoxy-21-chlorodexamethasone and dexamethasone 21-mesylate, as well as the first reported synthesis of dexamethasone 21-bromoacetate and dexamethasone 21-iodoacetate.