26990-64-7Relevant academic research and scientific papers
Identification of antitumor activity of pyrazole oxime ethers
Park, Hyun-Ja,Lee, Kyung,Park, Su-Jin,Ahn, Bangle,Lee, Jong-Cheol,Cho, HeeYeong,Lee, Kee-In
, p. 3307 - 3312 (2007/10/03)
A series of pyrazole oxime ether derivatives were prepared and examined as cytotoxic agents. In particular, 5-phenoxypyrazole was comparable to doxorubicin, while exhibiting very potent cytotoxicity against XF 498 and HCT15.
Introduction of N-containing heterocycles into pyrazole by nucleophilic aromatic substitution
Park, Min-Sup,Park, Hyun-Ja,Park, Koon Ha,Lee, Kee-In
, p. 1541 - 1550 (2007/10/03)
The nucleophilic aromatic substitution on 5-chloropyrazoles activated by the electron-withdrawing formyl group offers a useful method to introduce a wide range of N-containing heterocycles into them. The rate of reaction was greatly affected by the electronic nature of the N-1 substitution.
