27005-96-5

Basic information

• Product Name: 3-phenyl-4,5,6,7-tetrahydro-2H-indazole
• Synonyms: 3-phenyl-4,5,6,7-tetrahydro-2H-indazole
• CAS NO: 27005-96-5
• Molecular Weight: 198.268
• Mol File: 27005-96-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-phenyl-4,5,6,7-tetrahydro-2H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-4,5,6,7-tetrahydro-2H-indazole(27005-96-5)
• EPA Substance Registry System: 3-phenyl-4,5,6,7-tetrahydro-2H-indazole(27005-96-5)

Safety Data

• Hazardous Substances Data: 27005-96-5(Hazardous Substances Data)

Upstream product

• 17529-98-5 cyclopentanone p-tolylsulfonylhydrazone 
• 536-74-3 phenylacetylene 
• 108-94-1 cyclohexanone 
• 100-52-7 benzaldehyde 
• 3580-38-9 2-Benzoylcyclohexanone 

Relevant articles and documents

The Application of Microreactor Technology for the Synthesis of 1,2-Azoles

We demonstrate the successful synthesis of an array of 1,2-azoles within a borosilicate glass microreactor whereby conversions in the range of 98-100% were obtained. In terms of large-scale production, this corresponds to 0.339 g day-1 per microreactor when employing reagent concentrations of 1.0 M.

An Efficient Synthesis of Substituted Pyrazoles from One-Pot Reaction of Ketones, Aldehydes, and Hydrazine Monohydrochloride

An efficient, one-pot and metal-free process for the preparation of 3,5-disubstituted and 3,4,5-trisubstituted pyrazoles on multi-gram scale was developed. One-pot condensation of ketones, aldehydes and hydrazine monohydrochloride readily formed pyrazoline intermediates under mild conditions. Oxidation of pyrazolines, in situ, employing bromine afforded a wide variety of pyrazoles. The methodology offers a fast, and often chromatography-free protocol for the synthesis of 3,4,5-substituted pyrazoles in good to excellent yields. Alternatively, a more benign oxidation protocol affords 3,5-disubstituted or 3,4,5-trisubstituted pyrazoles by simply heating pyrazolines in DMSO under oxygen.