27005-96-5Relevant academic research and scientific papers
The Application of Microreactor Technology for the Synthesis of 1,2-Azoles
Wiles, Charlotte,Watts, Paul,Haswell, Stephen J.,Pombo-Villar, Esteban
, p. 28 - 32 (2004)
We demonstrate the successful synthesis of an array of 1,2-azoles within a borosilicate glass microreactor whereby conversions in the range of 98-100% were obtained. In terms of large-scale production, this corresponds to 0.339 g day-1 per microreactor when employing reagent concentrations of 1.0 M.
Microwave-assisted synthesis, biological assessment, and molecular modeling of aza-heterocycles: Potential inhibitory capacity of cholinergic enzymes to Alzheimer's disease
Galdámez, Antonio,Gutiérrez, Margarita,Henao, José A.,Morales-Bayuelo, Alejandro,Nú?ez, Yeray A. Rodríguez,Polo, Efraín,Prent-Pe?aloza, Luis,Ramos, Juan,Trilleras, Jorge,Valdés-Salas, Lady
, (2020/10/02)
A highly regioselective solvent-free microwave-assisted synthesis of pyrazoles and tetrahydroindazoles based on the condensation of 1,3-diketones with arylhydrazines is described. Compounds were evaluated as cholinesterase inhibitors in order to identify
An Efficient Synthesis of Substituted Pyrazoles from One-Pot Reaction of Ketones, Aldehydes, and Hydrazine Monohydrochloride
Lellek, Vit,Chen, Cheng-Yi,Yang, Wanggui,Liu, Jie,Ji, Xuebao,Faessler, Roger
supporting information, p. 1071 - 1075 (2018/02/26)
An efficient, one-pot and metal-free process for the preparation of 3,5-disubstituted and 3,4,5-trisubstituted pyrazoles on multi-gram scale was developed. One-pot condensation of ketones, aldehydes and hydrazine monohydrochloride readily formed pyrazoline intermediates under mild conditions. Oxidation of pyrazolines, in situ, employing bromine afforded a wide variety of pyrazoles. The methodology offers a fast, and often chromatography-free protocol for the synthesis of 3,4,5-substituted pyrazoles in good to excellent yields. Alternatively, a more benign oxidation protocol affords 3,5-disubstituted or 3,4,5-trisubstituted pyrazoles by simply heating pyrazolines in DMSO under oxygen.
Regioselective preparation of saturated spirocyclic and ring-expanded fused pyrazoles
Merchant, Rohan R.,Allwood, Daniel M.,Blakemore, David C.,Ley, Steven V.
, p. 8800 - 8811 (2015/01/08)
Saturated bicyclic pyrazoles represent an important class of biologically active molecules, but their preparation can be hampered by labor-intensive synthesis of required starting materials. A convenient one- or two-step procedure for the synthesis of sat
