27005-97-6

Basic information

• Product Name: 6-phenyl-7-oxabicyclo[4.1.0]heptan-2-one
• Synonyms: 6-phenyl-7-oxabicyclo[4.1.0]heptan-2-one
• CAS NO: 27005-97-6
• Molecular Weight: 188.226
• Mol File: 27005-97-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-phenyl-7-oxabicyclo[4.1.0]heptan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-phenyl-7-oxabicyclo[4.1.0]heptan-2-one(27005-97-6)
• EPA Substance Registry System: 6-phenyl-7-oxabicyclo[4.1.0]heptan-2-one(27005-97-6)

Safety Data

• Hazardous Substances Data: 27005-97-6(Hazardous Substances Data)

Upstream product

• 10345-87-6 3-phenylcyclohex-2-enone 
• 100-58-3 phenylmagnesium bromide 
• 5323-87-5 3-Ethoxycyclohex-2-en-1-one 

Downstream Products

• 110-94-1 1,5-pentanedioic acid 
• 1501-05-9 5-oxo-5-phenylvaleric acid 
• 244237-78-3 α-Hydroperoxybenzyl hydroperoxide 
• 15447-62-8 1-phenyl-hex-5-yn-1-one 
• 1198-34-1 2-Phenylcyclopentanone 

Relevant articles and documents

Asymmetric Construction of Alkaloids by Employing a Key ω-Transaminase Cascade

An ω-transaminase-triggered intramolecular aza-Michael reaction has been employed for the preparation of cyclic β-enaminones in good yield and excellent enantio- and diastereoselectivity, starting from easily accessible prochiral ketoynones and commercially available enzymes. The powerful thermodynamic driving force associated with the spontaneous aza-Michael reaction effectively displaces the transaminase reaction equilibrium towards product formation, using only two equivalents of isopropylamine. To demonstrate the potential of this methodology, this biocatalytic aza-Michael step was combined with annulation chemistry, affording unique stereo-defined fused alkaloid architectures.