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27017-66-9

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27017-66-9 Usage

Uses

2,?6-?Dichloro-?1,?5-?naphthyridine is a reagent used in the preparation of potential tau pathology PET tracers in the treatment of Alzheimer’s disease.

Check Digit Verification of cas no

The CAS Registry Mumber 27017-66-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,0,1 and 7 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 27017-66:
(7*2)+(6*7)+(5*0)+(4*1)+(3*7)+(2*6)+(1*6)=99
99 % 10 = 9
So 27017-66-9 is a valid CAS Registry Number.

27017-66-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,6-Dichloro-1,5-naphthyridine

1.2 Other means of identification

Product number -
Other names 1,5-Naphthyridine,2,6-dichloro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:27017-66-9 SDS

27017-66-9Relevant articles and documents

Discovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer’s Disease

Rombouts, Frederik J. R.,Andrés, José-Ignacio,Ariza, Manuela,Alonso, José Manuel,Austin, Nigel,Bottelbergs, Astrid,Chen, Lu,Chupakhin, Vladimir,Cleiren, Erna,Fierens, Katleen,Fontana, Alberto,Langlois, Xavier,Leenaerts, Joseph E.,Mari?n, Jonas,Martínez Lamenca, Carolina,Salter, Rhys,Schmidt, Mark E.,Te Riele, Paula,Wintmolders, Cindy,Trabanco, Andrés A.,Zhang, Wei,Macdonald, Gregor,Moechars, Dieder

, p. 1272 - 1291 (2017)

A mini-HTS on 4000 compounds selected using 2D fragment-based similarity and 3D pharmacophoric and shape similarity to known selective tau aggregate binders identified N-(6-methylpyridin-2-yl)quinolin-2-amine 10 as a novel potent binder to human AD aggreg

TAU PET IMAGING LIGANDS

-

, (2017/12/28)

The present invention relates to novel, selective radiolabelled tau ligands which are useful for imaging and quantifying tau aggregates, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue or a subject, in vitro or in vivo, and to precursors of said compounds.

1, 5-NAPHTHYRIDINE COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE

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, (2008/12/05)

The present invention provides a novel 1,5-naphthyridine compound represented by the following general formula [I]: wherein R1, R2, R4 and R5 each represent one selected from a hydrogen atom, a substituted or unsubstituted alkyl group, and the like; and R3 and R6 each represent one selected from a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, and the like.

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