27017-66-9Relevant articles and documents
Discovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer’s Disease
Rombouts, Frederik J. R.,Andrés, José-Ignacio,Ariza, Manuela,Alonso, José Manuel,Austin, Nigel,Bottelbergs, Astrid,Chen, Lu,Chupakhin, Vladimir,Cleiren, Erna,Fierens, Katleen,Fontana, Alberto,Langlois, Xavier,Leenaerts, Joseph E.,Mari?n, Jonas,Martínez Lamenca, Carolina,Salter, Rhys,Schmidt, Mark E.,Te Riele, Paula,Wintmolders, Cindy,Trabanco, Andrés A.,Zhang, Wei,Macdonald, Gregor,Moechars, Dieder
, p. 1272 - 1291 (2017)
A mini-HTS on 4000 compounds selected using 2D fragment-based similarity and 3D pharmacophoric and shape similarity to known selective tau aggregate binders identified N-(6-methylpyridin-2-yl)quinolin-2-amine 10 as a novel potent binder to human AD aggreg
TAU PET IMAGING LIGANDS
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, (2017/12/28)
The present invention relates to novel, selective radiolabelled tau ligands which are useful for imaging and quantifying tau aggregates, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue or a subject, in vitro or in vivo, and to precursors of said compounds.
1, 5-NAPHTHYRIDINE COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE
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, (2008/12/05)
The present invention provides a novel 1,5-naphthyridine compound represented by the following general formula [I]: wherein R1, R2, R4 and R5 each represent one selected from a hydrogen atom, a substituted or unsubstituted alkyl group, and the like; and R3 and R6 each represent one selected from a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, and the like.