27017-66-9

Usage

Uses

Used in Pharmaceutical Industry:
2,6-Dichloro-1,5-naphthyridine is used as a reagent for the preparation of potential tau pathology PET (positron emission tomography) tracers. These tracers are essential in the treatment and diagnosis of Alzheimer's disease, a neurodegenerative disorder characterized by the accumulation of tau protein in the brain. The compound plays a crucial role in developing diagnostic tools that can help visualize and monitor the progression of the disease, ultimately aiding in the development of effective therapeutic strategies.

Upstream product

• 27305-49-3 1,5-naphthyridine 1,5-dioxide 
• 254-79-5 1,5-naphthyridine 
• 462-08-8 pyridin-3-ylamine 
• 10025-87-3 trichlorophosphate 

Downstream Products

• 27017-70-5 1,5-dihydro-1,5-naphthyridine-2,6-dione 

Relevant academic research and scientific papers

Discovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer’s Disease

A mini-HTS on 4000 compounds selected using 2D fragment-based similarity and 3D pharmacophoric and shape similarity to known selective tau aggregate binders identified N-(6-methylpyridin-2-yl)quinolin-2-amine 10 as a novel potent binder to human AD aggreg

Linear-shaped thermally activated delayed fluorescence emitter using 1,5-naphthyridine as an electron acceptor for efficient light extraction

In this study, we developed a donor-π-acceptor-π-donor-type thermally activated delayed fluorescence (TADF) emitter (NyDPAc) using 1,5-naphthyridine as a core moiety. NyDPAc exhibited a high horizontal dipole ratio and thus a high external quantum efficiency (20.9%) even at a relatively low photoluminescence quantum yield (57%). 1,5-naphthyridine as an electron acceptor represents a promising core moiety for efficient TADF materials.

TAU PET IMAGING LIGANDS

The present invention relates to novel, selective radiolabelled tau ligands which are useful for imaging and quantifying tau aggregates, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue or a subject, in vitro or in vivo, and to precursors of said compounds.

SUBSTITUTED NAPHTHYRIDINES AS ACCEPTOR MOLECULES FOR ELECTRONIC DEVICES

The present invention provides the compounds of formula (1) wherein p is 1, 2, 3, 4, 5 or 6, and10 Ar1 is at each occurrence a 5 to 9 membered heteroaromatic moiety, which may be substituted with one or more substituents independently from each other selected from the group consisting of C1-20-alkyl, O-C1-20-alkyl, C(O)-C1-20-alkyl, C(O)-O-C1-20-alkyl, phenyl, F, Cl and Br, wherein C1-20-alkyl, C1-20-alkyl, O-C1-20-alkyl, C(O)-C1-20-alkyl and C(O)-O-C1-20-alkyl may be substituted with one or more substituents independently from each other selected from the group consisting of F, Cl, Br and phenyl, wherein phenyl may be substituted with one or more substituents independently from each other selected from the group consisting of F, Cl, Br and C1-10-alkyl, and electronic devices comprising these compounds.

1, 5-NAPHTHYRIDINE COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE

The present invention provides a novel 1,5-naphthyridine compound represented by the following general formula [I]: wherein R1, R2, R4 and R5 each represent one selected from a hydrogen atom, a substituted or unsubstituted alkyl group, and the like; and R3 and R6 each represent one selected from a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, and the like.

Chemistry of Heterocyclic Compounds. 61. Synthesis and Conformational Studies of Macrocycles Possessing 1,8- or 1,5-Naphthyridino Subunits Connected by Carbon-Oxygen Bridges

Polyethereal macrocycles were prepared from both 2,6-dichloro-1,5-naphthyridine (2) and 2,7-dichloro-1,8-naphthyridine (6).The "cross-the-face" structures of 1:1 macrocycles 7, derived from 2, were confirmed by NMR.The 2,7-(1,8-naphthyridino) macrocyclic structures 9 and 10 were also supported by NMR data which were indicative of diminished N-electron density, when compared to the parent 1,8-naphthyridine.Template reactions did not appreciably enhance product yields.The X-ray crystal structure of 1:1 macrocycle 9b was conducted and showed that the imidate moieties possess a nearly 0 deg dihedral angle and that the naphthyridine subunit exhibits marginal deviation from planarity.