27025-89-4Relevant academic research and scientific papers
General Platform for the Conversion of Isoxazol-5-ones to 3,5-Disubstituted Isoxazoles via Nucleophilic Substitutions and Palladium Catalyzed Cross-Coupling Strategies
Fernandes, Alessandra A. G.,da Silva, Amanda F.,Okada, Celso Y.,Suzukawa, Vitor,Cormanich, Rodrigo A.,Jurberg, Igor D.
, p. 3022 - 3034 (2019/05/17)
A general platform for the conversion of isoxazol-5-ones to 3,5-disubstituted isoxazoles has been developed via a two-step strategy. The first step leads to the formation of 5-(pseudo)halogenated isoxazoles, while in the second, a variety of heteroalkyl-, heteroaryl-, alkyl-, alkenyl-, alkynyl- and aryl-chains can be installed via nucleophilic substitutions or palladium catalyzed cross-coupling reactions.
NUCLEOPHILIC DISPLACEMENT OF THE METHOXY GROUP IN 5-METHOXYISOXAZOLE
Auricchio, Sergio,Ricca, Aldo,Truscello, Ada M.
, p. 297 - 298 (2007/10/02)
The reaction of 5-methoxy-3-phenylisoxazole, 1a, with primary and secondary alcohols in the presence of acids gives 5-alkoxy derivatives 1b-d in almost quantitative yields.
