27052-20-6

Usage

Uses

Used in Organic Synthesis:
(4-CHLOROBENZOYL)BENZOFURAN 97 is used as a key intermediate in the synthesis of various organic compounds. Its unique structure allows for the creation of a diverse range of molecules, making it a versatile building block in the development of new organic materials.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (4-CHLOROBENZOYL)BENZOFURAN 97 is utilized as a starting material for the development of novel drugs. Its chemical properties and structural features contribute to the design and synthesis of potential therapeutic agents, targeting a wide array of medical conditions.
Used as a Reference Standard in Analytical Chemistry and Spectroscopy:
(4-CHLOROBENZOYL)BENZOFURAN 97 also serves as a reference standard in the fields of analytical chemistry and spectroscopy. Its well-defined chemical structure and properties make it an ideal candidate for calibrating instruments and ensuring the accuracy of analytical measurements.

InChI:InChI=1/C15H9ClO2/c16-12-7-5-10(6-8-12)15(17)14-9-11-3-1-2-4-13(11)18-14/h1-9H

Upstream product

• 25917-49-1 1-(4-chlorophenyl)-2-(p-tolylsulfonyloxy)ethanone 
• 90-02-8 salicylaldehyde 
• 99-91-2 para-chloroacetophenone 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 271-89-6 1-benzofurane 
• 104-88-1 4-chlorobenzaldehyde 
• 132971-93-8 (E)-1-(4-chlorophenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 19158-57-7 (2-(4-chlorophenyl)-2-oxoethyl)dimethylsulfonium bromide 
• 68-12-2 N,N-dimethyl-formamide 
• 1679-18-1 4-Chlorophenylboronic acid 
• 125418-83-9 2-(2-formylphenoxy)acetonitrile 
• 676486-15-0 1-(4-chlorophenyl)-2-(dimethyl(oxo)-λ⁶-sulfanylidene)ethan-1-one 
• 50-00-0 formaldehyd 

Downstream Products

• 3611-72-1 α-(4-chlorophenyl)-2-benzofuranmethanol 
• 375839-19-3 benzofuran-2-yl-(4-chloro-phenyl)-methanone oxime 
• 55877-45-7 2-(4-chlorobenzyl)benzofuran 
• 82158-23-4 1(benzofuran-2-yl)-1(p-chlorophenyl)ethanol 

Relevant academic research and scientific papers

Synthesis method of benzofuran compound

The invention belongs to the field of organic chemical synthesis, and particularly relates to a synthesis method of a benzofuran compound. According to the invention, the reaction system adopts economical and efficient iron phthalocyanine as a catalyst, a

Potent α-amylase inhibitors and radical (DPPH and ABTS) scavengers based on benzofuran-2-yl(phenyl)methanone derivatives: Syntheses, in vitro, kinetics, and in silico studies

Thirty benzofuran-2-yl(phenyl)methanones 1–30 were synthesized and characterized their structures by spectroscopic techniques. Substituted phenacyl bromide and different derivatives of 2-hydroxy-benzaldehyde treated in the presence of anhydrous K2/s

Tandem addition/cyclization for synthesis of 2-aroyl benzofurans and 2-aroyl indoles by carbopalladation of nitriles

The first example of the palladium-catalyzed tandem addition/cyclization of 2-(2-acylphenoxy)acetonitriles with arylboronic acids has been developed, providing a new strategy for the synthesis of 2-aroyl benzofurans with excellent chemoselectivity and wid

2,3-Diaroyl benzofurans from arynes: Sequential synthesis of 2-aroyl benzofurans followed by benzoylation

A cascade synthetic strategy for the direct synthesis of 2-aroyl benzofurans from aryne precursors has been developed. This reaction proceeds via C-O and C-C bond cleavage as well as C-O and C-C bond formation in a single reaction vessel. The methodology provides good yields of 2-aroyl benzofurans and tolerates a variety of functional groups. The synthesized 2-aroyl benzofurans were further benzoylated at 3-positions and one of the synthesized 2,3-diaroyl benzofuran structures was confirmed unambiguously by X-ray crystallography.

Syntheses of 2-Aroyl Benzofurans through Cascade Annulation on Arynes

The highly efficient and expedient route for the syntheses of 2-aroyl benzofurans has been developed via the cascade [2+2] followed by a [4+1] annulation on arynes. The overall transformation proceeded through the formation of ortho-quinone methide by the

Palladium-catalyzed paraformaldehyde insertion: A three-component synthesis of benzofurans

An efficient procedure for 2-aroylbenzofuran preparation from 2-bromophenols, phenacyl bromides and paraformaldehyde is described. The cheap and stable paraformaldehyde served as the carbon source via an in situ formylation reaction.

Intramolecular oxidative coupling: I2/TBHP/NaN3-mediated synthesis of benzofuran derivatives

A novel intramolecular oxidative coupling reaction has been established to prepare benzofuran derivatives via direct C(sp2)-H functionalization for the formation of C-O bond. This transformation is mediated by I2/TBHP/NaN3 under metal-free conditions and a catalytic amount of NaN3 plays a crucial role in the reaction. Furthermore, the reaction tolerates a broad substrate scope with average to excellent yields.

Facile preparation of aromatic ketones from aromatic bromides and arenes with aldehydes

Aromatic ketones were efficiently prepared in good yields by the reactions of aryl bromides with n-BuLi, followed by the reactions with aromatic aldehydes or aliphatic aldehydes and the subsequent treatment with molecular iodine and K2CO3, in a one-pot method. The same treatment of arenes, instead of aromatic bromides, also provided the corresponding aromatic ketones in good yields. Using these methods, various diaryl ketones and alkyl aryl ketones bearing electron-rich aromatics and electron-deficient aromatics could be prepared efficiently by a simple, transition-metal-free, and therefore environmentally benign experimental procedure.