270574-63-5Relevant articles and documents
Production method of cimetidine
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Paragraph 0007; 0026; 0031-0032; 0037-0038; 0043, (2021/08/11)
The invention relates to a production method of cimetidine, the production method comprises the following steps: (1) reacting 2-chloroethanol with thiocyanate to prepare an intermediate (I); (2) reacting the intermediate (I) with methylamine to prepare an intermediate (II); (3) oxidizing the intermediate (II) with oxyacetic acid to obtain an intermediate (III); (4) condensing the intermediate (III) and cyanamide to obtain an intermediate (IV); and (5) condensing the intermediate (IV) and imidazole mercaptan (V) to prepare cimetidine. The production method of cimetidine is provided, the production method can avoid the environmental pollution caused by the by-product methyl mercaptan generated in the existing cimetidine production, and is simple in production process, low in production cost and suitable for industrial production.
Preparation method of cimetidine
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, (2021/08/06)
The invention discloses a preparation method of cimetidine. The preparation method comprises the following steps of (1) condensing 2-(4-methylimidazole-4-yl) methyl thioethylamine hydrochloride and CS2 in the presence of alkali, and preparing an intermediate (I) under the action of a desulfurization reagent, (2) reacting the intermediate (I) with monomethylamine to prepare an intermediate (II), and (3) in the presence of a desulfurization reagent, carrying out amination on the intermediate (II) and cyanamide to prepare cimetidine.
Cimetidine synthesis process
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Paragraph 0048-0059, (2019/11/12)
The invention relates to the technical field of biomedicine, in particular to a cimetidine synthesis process. The cimetidine synthesis process has high efficiency, damage to the human body and the environment can be reduced, and meanwhile the synthesis cost can be reduced. The synthesis process comprises the following steps: (1) mixing a first intermediate with a photocatalyst, and dissolving theobtained mixture in a reaction solvent; (2) adding a second intermediate to the reaction solution obtained in the step (1), and performing uniform mixing so as to obtain a clear solution; (3) using alight source to irradiate the clear solution obtained in the step (2), and performing coordinated stirring until it is shown through HPLC that the first intermediate reacts completely; and (4) performing concentration treatment so as to remove the solvent after completion of the reaction, and performing recrystallization by using water and isopropanol or ethanol so as to obtain cimetidine white powder.