270579-99-2Relevant academic research and scientific papers
Methods of enhancing renal uptake of oligonucleotides
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, (2008/06/13)
2′-O-Modified ribosyl nucleosides and modified methods containing such nucleosidic monomers are disclosed. Methods are disclosed that have increased binding affinity as shown by molecular modeling experiments. Methods are also disclosed for enhancing the renal uptake of oligomeric compounds as shown using a two-step HRP imunohistochemistry assay. The 2′-O-modified nucleosides of the invention include ring structures that position the sugar moiety of the nucleosides preferentially in 3′ endo geometries.
2′-O-aminoethyloxyethyl-modified oligonucleotides
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, (2008/06/13)
2′-O-Modified ribosyl nucleosides and modified oligomeric compounds containing such nucleosidic monomers are disclosed. Oligomeric compounds are disclosed that have increased binding affinity as shown by molecular modeling experiments. The 2′-O-modified nucleosides of the invention include ring structures that position the sugar moiety of the nucleosides preferentially in 3′ endo geometries.
2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides
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, (2008/06/13)
2'-O-Modified ribosyl nucleosides and modified oligonucleotides containing such nucleotides are disclosed. Oligonucleotides are disclosed that have increased binding affinity as shown by molecular modeling experiments. The 2'-O-modified nucleosides of the invention include ring structures that position the sugar moiety of the nucleosides preferentially in 3' endo geometries.
